Raynaud fenomeni ile basvuran hepatosellüler karsinom olgusu
A case of hepatocellular carcinoma associated with raynaund’s phenomenon
Özet
Hepatosellüler karsinom (HSK) klasik olarak sag üst kadran agrisi, karin siskinligi ve kilo kaybi ile kendini gösterir. HSK bazen paraneoplastik bulgularla birlikte olabilir. Bu manifestasyonlarin mekanizmalari iyi bilinmemektedir. Malignensi dijital iskemi birlikteligi ilk kez 1884 ve 1891 yillarinda rapor edilmistir. Bunu takiben az sayida ilerlemis mide ve özofagus kanseri ile Raynaud hastaligi birlikteligi rapor edilmistir. Raynaud fenomeni 50 yasin üzerinde baslamissa, parmaklarda asimetrik tutulum varsa siklikla paraneoplastiktir. Paraneoplastik Raynaud fenomeni tümör rezeksiyonundan sonra gerileyebilir. Bu makalede Raynaud fenomeni ile hepatosellüler karsinom birlikteligi olan bir olgu sunulmustur.
Abstract
Hepatocellular carcinoma (HCC) may present in one of several ways. The classical presentation is with right upper quadrant abdominal pain, abdominal swelling and weight loss. HCC may also be associated with several paraneoplastic manifestations. The mechanisms of these manifestations are not well known. The association of digital ischemia and malignancy was reported as early as 1884 and 1891. A few other reports followed in which Raynaud’s disease was associated with advanced stomach or esophageal cancer. Raynaud’s phenomenon first presenting at age 50 years or more, often with asymmetric involvement of fingers and evolution to necrosis, is frequently paraneoplastic. Occasionally, paraneoplastic Raynaud’s phenomenon remits after tumor resection. We report a case of hepatocellular carcinoma associated with Raynaud’s phenomenon
