Agustos 2023
Lokal ileri rektum kanserinde sagkalimi etkileyen faktörler - Tek merkez deneyimi
Factors affecting survival in locally advanced rectal cancer - Single center experience
- Ana Sayfa
- Sayılar
- Agustos 2023
- Lokal ileri rektum kanserinde sagkalimi etkileyen faktörler - Tek merkez deneyimi...
Özet
Giris ve Amaç: Rektum kanserinin prognozunu predikte edebilmek; hasta yönetiminde uygun tedaviyi uygulayabilmek, gereksiz tedavilerden kaçinabilmek ve medikal kaynaklari uygun kullanabilmek için önemlidir. Bu çalismada neoadjuvan kemoradyoterapi uygulanan lokal ileri rektum kanseri tanisi olan hastalarda sagkalim ile iliskili faktörleri arastirdik. Gereç ve Yöntem: 2014-2018 yillari arasinda Ankara Üniversitesi Tip Fakültesi Tibbi Onkoloji Bilim Dali’na basvuran lokal ileri rektum kanseri tanisi olan 78 hastanin klinik, patolojik, laboratuvar verileri hastane kayitlarindan retrospektif olarak tarandi. Sagkalim üzerine etkili faktörler log-rank testi ile degerlendirildi. Sagkalim analizleri Kaplan-Meier metodu ile yapildi. Bulgular: Çalismaya dahil edilen 78 hastanin ortanca yasi 61 idi. Hastalarin %34.6’si (n: 27) kadin, %65.4’ü (n: 51) erkek idi. Ortanca sagkalim süresi 62 ay olarak saptandi. Postoperatif N2 lenf nodu pozitifligi ve postoperatif tümör derecesi 3 olan, radyoterapinin tamamlanamadigi, adjuvan tedavi almayan ve ileri yasta olan hastalarda istatistiksel anlamli olarak toplam sagkalim daha kötü saptandi (p < 0.05). Sonuç: Neoadjuvan kemoradyoterapinin standart tedavi haline geldigi fakat radyoterapi uygulamasinin uzun süreli radyoterapi ya da kisa süreli radyoterapi olarak degisiklik gösterebildigi bu süreçte yas, radyoterapinin tamamlanmasi, postoperatif N2 nod pozitifligi, postoperatif tümör derecesi ve adjuvan tedavi sagkalimi etkileyen faktörler olarak tanimlandi.
Abstract
Background and Aims: Predicting the prognosis of rectal cancer is important in patient management to be able to apply appropriate treatment, to avoid overtreatment and to use medical resources appropriately. In this study, our aim is to investigate the factors associated with survival in patients with locally advanced rectal cancer who underwent neoadjuvant chemoradiotherapy. Materials and Methods: Clinical, pathological, and laboratory data of 78 patients with locally advanced rectal cancer who applied to Ankara University Faculty of Medicine, Department of Medical Oncology between 2014 and 2018 were retrospectively scanned from hospital records. Factors that may be associated with survival were evaluated with the log-rank test. Survival analyses were performed using the Kaplan-Meier method. Results: The median age of 78 patients included in the study was 61. 34.6% (n: 27) of the patients were female and 65.4% (n: 51) were male. The median survival time was 62 months. Elderly patients, patients in whom radiotherapy could not be completed, patients with postoperative N2 lymph node positivity and postoperative tumor grade 3, and patients who did not receive adjuvant therapy had significantly worse overall survival (p < 0.05). Conclusion: Age, completion of radiotherapy, postoperative N2 node positivity, postoperative tumor grade, and adjuvant therapy were defined as factors affecting survival in a period like which neoadjuvant chemoradiotherapy became the standard treatment, but radiotherapy could vary as long-term radiotherapy or short-term radiotherapy.
