Agustos 2023
Mide kanseri ve ABO kan grubu iliskisi: çok merkezli, gözlemsel, vaka-kontrol çalismasi
The relation between gastric cancer and ABO blood groups: multicenter, observational, case-control study
- Ana Sayfa
- Sayılar
- Agustos 2023
- Mide kanseri ve ABO kan grubu iliskisi: çok merkezli, gözlemsel, vaka-kontrol çalismasi...
Gazi Üniversitesi Tip Fakültesi, 2Tibbi Onkoloji Bilim Dali, Ankara
Dr. Abdurrahman Yurtaslan Onkoloji Egitim ve Arastirma Hastanesi, 3Onkoloji Klinigi, Ankara
Hatay Devlet Hastanesi, 4Onkoloji Bölümü, Antakya, Hatay
Özet
Giris ve Amaç: Bu çalismanin amaci, kan gruplari ile mide kanseri riski arasindaki iliskiyi arastirmaktir. Gereç ve Yöntem: Çok merkezli, gözlemsel, vaka-kontrol çalismasina 2000-2016 yillari arasinda mide kanseri tanisi ile takip edilen ve serolojik olarak ABO kan grubu belli olan hastalar dahil edildi. Kontrol grubu olarak ise Türk Kizilayi’na kan bagisinda bulunan saglikli kisiler seçildi ve saglikli kisilerin kan gruplarina Türk Kizilayi’nin kayitlarindan ulasildi. Istatistiksel analizler için SPSS versiyon 13 kullanildi. Bulgular: Mide kanseri tanisi olan grup ile kontrol grubu arasinda kan gruplari açisindan dagilimlar istatistiksel olarak farkli idi. Mide kanseri tanisi olan hastalarda A kan grubu daha fazla görülmekteydi (p < 0.001). Gruplar O grubu, non-O grubu olarak siniflandirildiginda; mide kanseri tanisi olan grupta hastalarin %29’unda (n: 253) O grubu, %71’inde (n: 627) non-O grubu tespit edildi. Kontrol grubunda ise vakalarin %34’ünde O grubu ve %66’sinda non-O grubu saptandi. Mide kanseri tanisi olan hastalar ile kontrol grubu karsilastirildiginda mide kanserli hastalarda O grubu disi kan gruplarinin daha fazla görüldügü tespit edildi (p: 0.010). Sonuç: Bu çalismada, daha önce farkli ülkelerde yapilmis çalismalara benzer olarak ülkemizde de O disi (özellikle A grubu) kan grubuna sahip olmak artmis mide kanseri riski ile iliskili bulundu.
Abstract
To investigate the relationship between ABO blood groups and gastric cancer risk. Materials and Methods: Patients who were followed up with a diagnosis of gastric cancer between 2000 and 2016 and whose ABO blood group was determined serologically were included in the multicenter, observational, case-control study. As the control group, healthy people who donated blood to the Turkish Red Crescent were selected and the blood groups of the healthy people were obtained from the records of the Turkish Red Crescent. SPSS version 13 was used for statistical analysis. Results: The distributions in terms of blood groups were statistically different between the group diagnosed with gastric cancer and the control group. A blood group was more common in patients with gastric cancer (p < 0.001). When blood groups classified as O group and non-O group; in the group diagnosed with gastric cancer, 29% (n: 253) of the patients were O group, 71% (n: 627) were non-O group; in the control group, O group was detected in 34% and non-O group was detected in 66% of the cases. When patients with gastric cancer and the control group were compared, it was found that non-O blood groups were more common in patients with gastric cancer (p: 0.010). Conclusion: In this study, having non-O (especially group A) blood group in our country was found to be associated with an increased risk of gastric cancer, similar to previous studies in different countries.
