Nisan 2022
Clostiridium difficile enfeksiyonuna eslik eden protein kaybettiren enteropati olgusu
Protein-losing enteropathy associated with Clostiridium difficile infection: A case report
- Ana Sayfa
- Sayılar
- Nisan 2022
- Clostiridium difficile enfeksiyonuna eslik eden protein kaybettiren enteropati olgusu...
Özet
Protein kaybettiren enteropati, plazma proteinlerinin lenfatik obstrüksiyon, sag kalp basincinin arttigi kalp hastaliklari ve gastrointestinalsistemden kaybi ile karakterize nadir görülen bir hastaliktir. Primer intestinal lenfanjiektazi protein kaybettiren enteropatinin en sik nedeni olmaklabirlikte Giardia intestinalis, Clostiridium difficile gibi pek çok parazitik enfeksiyonlar, inflamatuvar barsak hastaligi, çölyak, malignite, kardiyakhastaliklar ve kollajen doku hastaliklarinin protein kaybettiren enteropatiye neden oldugu bilinmektedir. Clostiridium difficile antibiyotik iliskili kolitinen önemli enfeksiyonlarindan biri olup semptomatik ya da asemptomatik olabilir. Sulu ishal, karin agrisi sik klinik bulgu iken bazi olgularda barsakduvarinin enflamasyonu ve kolon lümeninin içerisine albümin sizmasi ile iliskili olarak hipoalbüminemi ve ödem diger klinik bulgulari olusturmaktadir. Bize antibiyotik kullanimi sonrasi ishal, ödem klinigi ile basvuran, laboratuvar ve histopatolojik olarak lenfanjiektazi ile uyumlu saptanan olgu,protein kaybettiren enteropati olarak degerlendirildi. Az sayida literatürde Clostiridium difficile enfeksiyonuna bagli protein kaybettiren enteropatigelistigi bildirildiginden bu olgu sunulmak istendi.
Abstract
Protein-losing enteropathy is a rare disease characterized by lymphatic obstruction, heart disease with increased right heart pressure, and loss of proteins through the gastrointestinal tract. Although primary intestinal lymphangiectasia is the most common cause of protein-losing enteropathy, many parasitic infections such as Giardia intestinalis, Clostridium difficile, inflammatory bowel diseases, celiac diseases, malignancies, cardiac diseases, and collagen tissue diseases cause protein-losing enteropathy. Clostridium difficile is one of the most important causes of antibiotic-associated colitis, and it can be either symptomatic or asymptomatic. Although watery diarrhea and abdominal pain are common clinical findings, in some cases, hypoalbuminemia and edema are other clinical findings associated with inflammation of the intestinal wall and albumin leakage into the lumen of the colon. The patient who presented to us with diarrhea and edema after using antibiotics, their case was found to be laboratory and histopathologically compatible with lymphangiectasia, and it was evaluated as protein-losing enteropathy. Here, we present this case because of the scant reports of protein-losing enteropathy caused by Clostridium difficile infection.
