Agustos 2021
Yaslilarda kandida özofajiti: Tek merkez deneyimi
Candida esophagitis in elderly patients: A single center experience
- Ana Sayfa
- Sayılar
- Agustos 2021
- Yaslilarda kandida özofajiti: Tek merkez deneyimi...
Özet
Giris ve Amaç: Kandida özofajiti, özofagus mukozasinin fungal enfeksiyonudur. Bu çalismada amaç; insan immün yetmezlik virüsü negatif yaslilarda kandida özofajiti ile iliskili olarak predispozan faktörleri belirlemek ve eslik eden endoskopi bulgularini sunmaktir. Gereç ve Yöntem: Bu çalisma; herhangi bir nedenle endoskopi yapilip, kandida özofajiti tanisi koyulan, insan immün yetmezlik virüsü (-), ? 65 yas hastalarin retrospektif tek merkezli irdelenmesini içermektedir. Hastalarin yas, cinsiyet, eslik eden hastaliklari, insan immün yetmezlik virüsü enfeksiyonu varligi, kullandigi ilaçlari, Diabetes Mellitus varligi, proton pompa inhibitörü kullanimi, örneklemenin nasil yapildigi, basvuru semptomlari ve endoskopi yapilma nedenleri taranmistir. Bulgular: Bu çalismada 65 yas üstü olup endoskopi yapilan toplam 2462 hastanin 16’sinda (%0.65) kandida özofajiti saptanmistir. Kandida özofajiti saptanan hastalarin yaslari 65 ile 88 arasinda olup yas ortalamasi 76.75 ± 7.9 yildir. Hastalarin 8’i (%50) kadindir. Hastalarin en sik semptom ve endoskopi yapilma nedeni 8 (%50) hastada disfajidir. Hastalarin 5’inde (%31.3) Diabetes Mellitus tanisi saptanmistir. Hastalarin ilaç kullanimlari incelendiginde; 6’si- nin (%37.5) sürekli proton pompa inhibitörü kullandigi, 5’inin (%31.3) son 1 ay içerisinde antibiyotik kullanim öyküsü oldugu anlasilmistir. On dört hastadan (%87.5) biyopsi forsepsi ile, 2 hastadan (%12.5) ise fir- çalama teknigi ile örnek alinarak taniya gidilmistir. Sonuç: Bu çalisma, bildigimiz kadariyla ülkemizde geriatrik popülasyonda kandida özofajiti ile iliskili ilk çalismadir. Çalismamizda insan immün yetmezlik virüsü (-), kandida özofajiti olan geriatrik hastalarin yas etkeni yaninda kullanilan ilaçlarin ve komorbiditelerin de risk faktörü oldugu, bu hastalarda semptomlarin degiskenlik gösterebildigi akilda tutulmalidir
Abstract
Background and Aims: Candida esophagitis is a fungal infection of the esophageal mucosa. This study aimed to determine the predisposing factors and accompanying endoscopy findings associated with Candida esophagitis in human immunodeficiency virus-negative elderly patients. Materials and Methods: This was a retrospective single center study involving human immunodeficiency virus-negative patients aged ?65 years old who underwent endoscopy for any reason and were diagnosed with Candida esophagitis. The age, sex, accompanying diseases, presence of human immunodeficiency virus infection, drugs used, presence of Diabetes Mellitus, use of proton pump inhibitor, how the sampling was done, symptoms at presentation, and the reason for performing endoscopy were reviewed. Results: Candida esophagitis was found in 16 (0.65%) out of 2462 patients aged over 65 years who underwent endoscopy. The patients with Candida esophagitis were aged between 65 and 88 years, with an average age of 76.75 ± 7.9 years. Eight (50%) of the patients were female. Dysphagia was the most common symptom and reason for endoscopy in eight (50%) patients. Diabetes Mellitus was diagnosed in five (31.3%) of the patients. When the drug use of the patients was examined, it was reported that six (37.5%) patients were using proton pump inhibitor continuously, and five (31.3%) patients had a history of antibiotic use in the last one month. The diagnosis was made using biopsy forceps in 14 (87.5%) patients and the brushing technique in two (12.5%) patients. Conclusion: To our knowledge, this is the first study investigating Candida esophagitis in the geriatric population in our country. We suggest that drug use and comorbidities, as well as age factor, were risk factors for Candida esophagitis in geriatric human immunodeficiency virus -negative patients, and symptoms may vary in these patients
