Aralik 2020
COVID-19’da gastrointestinal semptomlar ile hastaligin seyri ve prognozu arasinda bir iliski var mi? Tek merkezli pilot çalisma
Is there a relationship between gastrointestinal symptoms and disease course and prognosis in COVID-19? A single-center pilot study
- Ana Sayfa
- Sayılar
- Aralik 2020
- COVID-19’da gastrointestinal semptomlar ile hastaligin seyri ve prognozu arasinda bir iliski var mi? Tek merkezli pilot çalisma...
Osmangazi Üniversitesi Tip Fakültesi, 3Gastroenteroloji Klinigi, Eskisehir
Özet
Giris ve Amaç: Pandemi yapan ve çok fazla ölüm nedeni olan COVID-19 genelde solunumsal semptomlarla prezente olsa da bazen busemptomlara gastrointestinal semptomlar da eslik etmektedir. Çalismamizda COVID-19 hastalarinda gastrointestinal semptomlarin sikligini veprognozla iliskisini arastirmayi amaçladik. Gereç ve Yöntem: 11 Mart2020-30 Nisan 2020 tarihleri arasinda Bilecik Devlet Hastanesine basvuran ve real time polimeraz zincir reaksiyonu ile tanisi konulan 110 hastanin demografik, radyolojik, laboratuvar ve klinik açidan analizi yapildi.Bulgular: Hastaneye basvuru esnasinda 13 (%11.8) hastada bir veyadaha fazla gastrointestinal semptom vardi. Biyokimyasal parametrelerden D-dimer ve fibrinojen artisiyla gastrointestinal semptomlar arasindabelirgin iliski vardi (p <0.001). gastrointestinal semptom varligi hastaliksiddeti ile iliskiliydi (p=0.012) ve hastalik siddetini öngörmede yüksekprediktif degere sahipti (Odds Ratio=7.2). Sonuç: COVID-19 nadirensadece gastrointestinal semptomlarla prezente olabilmektedir. Pandemidöneminde gastrointestinal semptomu olan hastalarda COVID-19 akilda tutulmali ve saglik çalisanlari bu konuda uyanik olmalidir ve korunmaadina gerekli tedbirlerini almalidirlar. Ayrica bu hastalarin erken tespitedilmesi ile hastaligin daha fazla yayilmasi engellenebilecektir.
Abstract
Background and Aims: Although COVID-19 pandemic that causes many deaths is usually presented with respiratory symptoms, thesymptoms are often accompanied by gastrointestinal symptoms. Inour study, we aimed to investigate the frequency of gastrointestinalsymptoms in COVID-19 patients and their relationship with prognosis.Materials and Methods: Demographic, radiological, laboratory, andclinical analyses were conducted on 110 patients who submitted toBilecik State Hospital between 11 March 2020 and 30 April 2020. Furthermore, a real-time polymerase chain reaction was used to diagnoseCOVID-19. Results: During hospital admission, 13 (11.8%) patients hadone or more gastrointestinal symptoms. There was an increase in theoccurrence of gastrointestinal symptoms with age (p=0.062). In addition, there was a strong correlation between GI symptoms with D-dimerand fibrinogen increase from biochemical parameters (p<0.01). Theoccurrence of gastrointestinal symptoms was associated with diseaseseverity (p = 0.012) and had a high predictive value when predicting disease severity (OR = 7.2). Conclusion: COVID-19 can rarely be presented with only gastrointestinal symptoms. Moreover, COVID-19 shouldbe kept in mind in patients with gastrointestinal symptoms during thepandemic period, and health workers should be cautious and take appropriate precautions for protection. In addition, early identification ofthese patients will prevent further spread of the disease.
