Tip 2 diabetes mellitus ve hepatosteatoz
Type 2 diabetes mellitus and hepatosteatosis
Özet
Giris ve amaç: Diabetes mellitus, anormal karaciger enzim yüksekligi, hepatosteatoz ve nadiren siroza kadar gidebilen karaciger hasarina neden olabilmektedir. Bu çalismada tip 2 diabetes mellitus ile hepatosteatoz arasindaki iliski arastirildi. Gereç ve yöntem: 12’si erkek 68’i kadin 80 tip 2 diabetik hasta çalismaya alindi. Beden kitle indeksi (BKI), açlik ve tokluk kan sekeri, HbA1c, total kolesterol, LDL, HDL kolesterol, trigliserid ve yüzde yag orani ölçüldü. Hastalar diabetik mikrovasküler komplikasyonlar açisindan incelendiler. Hepatosteatoz varligi ultrasonografi ile degerlendirildi. Bulgular: 44 (% 52) hastada diabetik mikrovasküler komplikayon tespit edildi. 80 tip 2 diabetik hastanin 75’inde hepatosteatoz tespit edildi. 34 hastada 1. derecede, 25 hastada 2. derecede, 16 hastada 3. derecede hepatosteatoz saptandi. Tip 2 diabetik hastalarda hepatosteatoz derecesi ile hastalarin BKI’i arasinda iliski tespit edilmezken diabet süresi ile hepatosteatoz derecesi arasinda istatistiksel anlamli pozitif korelasyon gözlenmistir (r=0.76, p<0.001). Sonuç: Bu sonuçlar, diabetes mellitusun hepatosteatoz ile direk iliskili oldugunu desteklemektetir.
Abstract
Background and aims: Diabetes can cause abnormal liver functions which can present as elevated liver enzymes, hepatosteatosis and even cirrhosis. The purpose of this study was to identify the significance and clinical correlation of steatosis in patients with type 2 diabetes mellitus. Material and methods: Eighty type 2 diabetic patients (12 men, 68 women) were included in this study. Body mass index (BMI), fasting and postprandial blood glucose, HbA1c, total cholesterol, LDL and HDL cholesterol, triglycerides and fat percentage were measured. Diabetic microvascular complications were also evaluated. The presence of steatosis in type 2 diabetic patients was evaluated by ultrasound. Results: Forty-four (52% ) patients had diabetic microvascular complications. Seventy-five of the diabetic patients had hepatosteatosis (34 with grade 1 hepatosteatosis, 25 with grade 2 hepatosteatosis, 16 with grade 3 hepatosteatosis). There was no significant positive correlation between hepatosteatosis grade but BMI and there was a significant correlation between diabetes age and hepatosteatosis grade (r=0.76, p<0.001). Conclusions: These results suggest that diabetes mellitus is directly related to hepatosteatosis.
