Agustos 2017
Interferon kullanimi ile ilişkili retinopati: Olgu sunumu
Retinopathy associated with interferon: Case report
- Ana Sayfa
- Sayılar
- Agustos 2017
- Interferon kullanimi ile ilişkili retinopati: Olgu sunumu ...
Özet
Interferon tedavisi antiviral etkisi yaninda, hücre proliferasyonunu baskilamak, immün sistemi düzenlemek gibi degisik nedenlerle kulanilmaktadır. BU ilaçlarin neoplastik hastalıklar, kronik viral hepatit tedavisi yaninda vasküler endotelyal hücre proliferasyonu ve anjiogenezi baskilama gibi etkileri de vardır. Interferon tedavisinin degisik yan etkileri bulunmaktadır. Retinopati, konjunktiva alti kanamalari gibi oküler toksisiteleri de bilinir. Biz burada; kronik hepatit C tanısı alan ve interferon +ribavirin tedavisi sonrasi retinopati gelişen bir vakayi sunacagiz. Hastanın oküler yan etkilerden dolayi interfeon tedavisinin kesilmesine ragmen oküler bulgular uzun süre sebat etmıştır.
Abstract
Interferon therapy has been known to produce various responses, such as creating an antiviral effect, inhibiting cell proliferation, and modulating immunity. It has been used to treat various systemic disorders, including neoplastic disease and chronic hepatitis. The agent is also known to inhibit vascular endothelial cells and angiogenesis. Various adverse effects of interferon therapy have been reported. Interferon is also known to cause ocular toxicity such as retinopathy and subconjunctival hemorrhages. Thirty patients with chronic hepatitis C between 21 and 52 years of age (female 16, male 14; mean age 40.6) were treated with interferon 2 alpha and ribavirin. Seventeen patients experienced different side effects, and one patient developed ocular toxicity. We dropped out because of ocular side effects but ocular finding were lasted.
