Aralik 2015
Eriskin dispeptik hastalarda gastrik bulgular ile hipotirodi ve tiroit otoantikor pozitifligi prevalansi arasindaki Iliski
The relationship between gastric findings, hypothyroidism and thyroid autoantibody positivity in adult dyspeptic patients
- Ana Sayfa
- Sayılar
- Aralik 2015
- Eriskin dispeptik hastalarda gastrik bulgular ile hipotirodi ve tiroit otoantikor pozitifligi prevalansi arasindaki Iliski...
Özet
Giris ve Amaç: Gastrik hastaliklarin iyot metabolizmasini etkileyerek tiroit hastaliklarina neden olabildigi ve Helicobacter pylori enfeksiyonunun otoimmün hastaliklarin gelismesinde rol oynadigi bilinmektedir. Biz bu çalismada gastrik endoskopik ve histopatolojik bulgular ile hipotiroidi ve tiroit otoantikor pozitifligi prevalansi arasindaki iliskiyi degerlendirmeyi amaçladik. Gereç ve Yöntem: Çalismaya 1 Ocak 2014-31 Mart 2014 tarihleri arasinda Ankara Keçiören Egitim ve Arastirma Hastanesi Gastroenteroloji Poliklinigi’ne dispeptik sikayetlerle basvuran ve üst gastrointestinal sistem endoskopisi yapilarak gastrik biyopsi alinan 18-75 yaslari arasinda kisiler dahil edildi. Katilimcilardan alinan serum örneklerinden tiroit stimüle edici hormon, serbest T3, serbest T4, antitiroit peroksidaz antikoru, anti-tiroglobulin antikoru çalisildi. Bulgular: Çalismaya 154 hasta dahil edildi. Tüm çalisma grubunun %89’u (137 kisi) ötiroit ve %11’i (17 kisi) hipotiroit idi. Endoskopik ve histopatolojik bulgularina göre farkli gruplara ayrilmis hastalar arasinda hipotiroidi ve tiroit otoantikor pozitifligi saptanan hastalarin prevalansi açisindan anlamli fark gözlenmedi (p>0.05). Sonuç: Gastrik hastaliklar ile hipotirodi ve otoimmün tiroit hastaligi prevalansi arasinda anlamli bir iliski mevcut degildir. Bulgularin dogrulanmasi için daha genis ölçekli çalismalara ihtiyaç duyulmaktadir.
Abstract
Background and Aims: It is known that gastric diseases can lead to thyroid diseases by affecting iodine metabolism. It is also known that Helicobacter pylori infection can trigger autoimmune diseases. In the current study, we aimed to evaluate the association between gastric endoscopic and histopathologic findings with the prevalence of patients with hypothyroidism or thyroid autoantibody positivity. Materials and Methods: Individuals with dyspeptic complaints, between the ages of 18-75, who underwent upper gastrointestinal endoscopy and gastric biopsy at the Ankara Keçiören Training and Research Hospital Gastroenterology Department between 1 January 2014-31 March 2014, were enrolled in the study. Thyroid stimulating hormone, free T3, free T4, anti-thyroid peroxidase antibody and antithyroglobulin antibody were measured from participants’ serum samples. Results: 154 patients were included in the study, 89% (n=137) were euthyroid, 11 % (n=17) hypothyroid. There were no significant differences in terms of prevalence of patients with hypothyroidism or thyroid auto-antibody positivity between individuals who were grouped depending on endoscopic and histopathologic findings (p>0.05). Conclusion: There was no significant relationship between the gastric findings and the prevalence of patients’ hypothyroidism or thyroid autoantibody. There is need for further studies to confirm these findings.
