Agustos 2012
inflamatuvar barsak hastaligi olan hastalarda tiroid hormonlari ve otoantikorlarinin degerlendirilmesi
Evaluation of thyroid hormones and autoantibodies in patients with inflammatory bowel disease
- Ana Sayfa
- Sayılar
- Agustos 2012
- inflamatuvar barsak hastaligi olan hastalarda tiroid hormonlari ve otoantikorlarinin degerlendirilmesi...
Özet
Giris ve Amaç: inflamatuvar barsak hastaliklari patogenezi tam olarak bilinmeyen, beraberinde pek çok ekstraintestinal manifestasyonlari da olabilen hastaliklardir. Beraberinde görülebilen hastaliklardan biri de otoimmun tiroid hastaliklaridir. Bizim çalismadaki amacimiz Crohn hastaligi ve ülseratif kolitte tiroid hormonlari ve tiroid otoantikorlarinin düzeyini degerlendirmekti. Gereç ve Yöntem: Poliklinige basvuran insamatuar barsak hastaligi olan hastalar TSH, FT3, FT4, anti-TPO, anti-TG açisindan degerlendirildi. Bulgular: Çalismaya 119 ülseratif kolit, 36 Crohn hastaligi olmak üzere toplam 155 hasta dahil edildi. Ülseratif kolitlilerin 23?ünde (%19,3) Crohn hastalarinin 4?ünde (%11,1) otoantikor yüksekligi saptandi. 3 ülseratif kolit hastasinda subklinik hipotiroidi saptandi. Ülseratif kolit hastalarinin 7?sinde Crohn hastalarinin 1?inde subklinik hipertiroidi saptandi. Daha önce hipotiroidi tanisi olan 1 ülseratif kolit ve 1 Crohn hastasi disinda yeni saptanan hipotiroidi veya hipertiroidi olmadi. Otoantikor yüksekligi ve tiroid hastaliklari açisindan her iki hastalik arasinda istatistiksel olarak anlamli fark bulunmadi. Sonuç: Çalismamizda artmis bir hipotiroidi veya hipertiroidi orani saptanmasa da, artmis tiroid otoantikor düzeyi olan hastalarin yüksek orani, inflamatuvar barsak hastaligi ve tiroid hastaliklarinin bir arada bulunabilecegini düsündürmektedir. ileri arastirmalara ihtiyaç vardir.
Abstract
Background and Aims: Inflammatory bowel diseases are diseases with unknown pathogenesis, and many concomitant extraintestinal manifestations can be seen. One of the concomitant diseases is autoimmune thyroid disease. The aim of our study was to evaluate thyroid hormones and autoantibody levels in Crohn?s disease and ulcerative colitis. Materials and Methods: Inflammatory bowel diseases patients who applied to the outpatient clinic were evaluated for thyroid stimulating hormone, FT3, FT4, anti-thyroid peroxidase and antithyroglobulin. Results: A total of 155 patients (119 ulcerative colitis and 36 Crohn?s disease) were enrolled into the study. Autoantibodies were detected in 23 patients (19.3%) with ulcerative colitis and 4 patients (11.1%) with Crohn?s disease. Subclinical hypothyroidism was found in 3 patients with ulcerative colitis. Subclinical hyperthyroidism was found in 7 patients with ulcerative colitis and 1 patient with Crohn?s disease. No new cases of hypothyroidism or hyperthyroidism were found except 1 ulcerative colitis patient and 1 Crohn?s disease patient, who were previously diagnosed as hypothyroid. No difference was found between these two diseases regarding autoantibodies and thyroid diseases. Conclusions: Although no increase in the rate of hypothyroidism or hyperthyroidism was found, the high rate of autoantibodies detected suggests that inflammatory bowel diseases and thyroid disease can be found together. Further studies are required.
