Agustos 2011
Kronik hepatit B ve kronik hepatit C’ye bagli gelisen sirozlu hastalarda safra kesesi tasi sikligi
The frequency of cholelithiasis in patients with cirrhosis due to chronic hepatitis B and chronic hepatitis C
- Ana Sayfa
- Sayılar
- Agustos 2011
- Kronik hepatit B ve kronik hepatit C’ye bagli gelisen sirozlu hastalarda safra kesesi tasi sikligi...
Özet
Birçok çalismada, sirozda safra kesesi tasi prevalansinin normal popülasyona göre arttigi bildirilmistir. Bu çalismada kronik hepatit B ve kronik hepatit C’ye bagli gelisen karaciger sirozu nedeniyle takipli hastalardaki safra kesesi tasi sikligi ve bunun yas, cinsiyet, hastalik etiyolojisi ile iliskisinin arastirilmasi planlanmistir. Gereç ve Yöntem: Çalismamizda 2005–2010 yillari arasinda Haydarpasa Numune Egitim ve Arastirma Hastanesi Gastroenteroloji klinigine basvuran, 18–70 yas araligindaki kronik hepatit B, kronik hepatit C ve bunlara bagli siroz gelismis olan toplam 305 hasta incelendi. Kronik hepatit B ve kronik hepatit C hastalari, bunlara bagli siroz gelismis hastalar yas, cinsiyet, safra kesesi tasi sikligi açisindan karsilastirildi. Bulgular: Siroz tanisi olan hasta sayisi 67 (33 kadin, 44 erkek) olup yas ortalamasi 54±13 idi. Sirozlu 67 olgunun 12’sinde safra kesesi tasi tespit edilmis olup, bu 12 hastada kadin (4,%33,3) ve erkek (8, %66,7) cinsiyet açisindan istatistiksel olarak anlamli fark bulunmamistir. HBV’ye bagli sirozlu olgularla, HCV’ye bagli sirozlu olgular arasinda safra kesesi tasi varligi açisindan istatiksel bir fark saptanmadi. Ancak HBV’li olgularda safra kesesi tasi sikligi daha sik izlenmistir. Sonuç: Hastalarimizda sirozlu olgularda safra kesesi tasi görülme sikligi %17,9 olarak saptanmistir. Bu oran daha önce ülkemizden bildirilen safra kesesi tasi sikligi oranlariyla (%7-30) benzerdir. Sirozlu olgularin safra kesesi tasi açisindan erken tani ve takibi yararli olacaktir.
Abstract
Many studies have shown that the prevalence of cholelithiasis in cirrhosis is increased 2-5 times compared to the normal population. In this study, patients followed with liver cirrhosis due to chronic hepatitis B and chronic hepatitis C were investigated regarding the prevalence of cholelithiasis (gallstones) and the relation of this with age, gender and etiology of the disease. Materials and Methods: A total of 305 patients between the ages of 18-70 years with cirrhosis due to chronic hepatitis B and chronic hepatitis C were enrolled in the study. Patients with chronic hepatitis B and chronic hepatitis C and the patients with cirrhosis were compared with regard to age, gender and the frequency of cholelithiasis. Results: There were 67 patients (33 female, 44 male) with cirrhosis, and the mean age was 54±13 years. Cholelithiasis was determined in 12 of 67 patients with cirrhosis, and when they were examined in terms of gender, there was no significant difference between female (4, 33.3%) and male (8, 66.7%) patients. No statistically significant difference was found regarding the presence of cholelithiasis between the patients with cirrhosis due to hepatitis B or hepatitis C. However, the frequency of cholelithiasis was greater in patients with hepatitis B. Conclusions: The incidence of cholelithiasis in patients with cirrhosis is 17.9%. This is similar to the rates that have been reported previously about the frequency of cholelithiasis (7-30%). It would be useful to observe the patients with cirrhosis for early diagnosis and treatment of cholelithiasis.
