Agustos 2011
Mide kanserli olgularda malnütrisyonun immün, biyokimyasal, antropometrik fonksiyonlara etkileri
Effects of immune, biochemical and anthropometric function in stomach cancer patients with malnutrition
- Ana Sayfa
- Sayılar
- Agustos 2011
- Mide kanserli olgularda malnütrisyonun immün, biyokimyasal, antropometrik fonksiyonlara etkileri ...
Özet
Bu çalisma mide kanserli olgularda enteral ve total parenteral nutrisyonun, antropometrik, biyokimyasal ve immün fonksiyonlara olan etkilerini karsilastirmak için yapilmistir. Gereç ve Yöntem: Ankara Numune Egitim ve Arastirma hastanesi 6. Genel Cerrahi Kliniginde 1996–2006 tarihlerinde mide kanserli 78 olguya nutrisyon destegi verildi. Tüm olgularin nutrisyon ile ilgili indeksleri ölçülerek retrospektif olarak kaydedildi. Istatistiksel analiz için Mann Whitney-U testinden yararlanildi. P<0.05 anlamli kabul edildi. Bulgular: Olgularin yas ortalamalari enteral nutrisyon grubunda 59.3±12.6, total parenteral nutrisyon grubunda 58.1±11.9 olarak saptandi. Bunlarin 60’i erkek (%76.8), 18’i kadindi (%23.2). Olgularin 32 (%41.0)’si 9.5±5.7 gün enteral nutrisyon, 46 (%59.0)’si ise 10.7±6.4 gün total parenteral nutrisyon almislardir (p=0.146). Malnütrisyon durumunu belirleyen Yüzeyel Global Degerlendirme ile enteral nutrisyon grubunda 12 (%37.5) olgunun ciddi düzeyde malnutrisyonlu oldugu belirlenirken, ayni ölçüm, total parenteral nutrisyon grubunda 15 (%32.6) oldu (p=0.096). Ig G ve Ig A degerleri, enteral nutrisyon grubunda daha yüksekti (sirasiyla; p=0.001, p=0.036), Ig M degerlerinde ise farklilik yoktu (p=0.079). Sonuç: Mide kanserli hastalarda, enteral veya total parenteral nutrisyonla, antropometrik ve biyokimyasal parametrelerde farklilik olmamasina karsin, immün sisteme ait parametrelerde enteral nutrisyon lehine farkliliklar olmaktadir.
Abstract
In this study, enteral and total parenteral nutrition in patients with gastric cancer was compared with respect to anthropometric, biochemical and immune functions. Materials and Methods: Nutritional support was given to 78 gastric cancer patients in the general surgery clinic of Ankara Numune Training and Research Hospital during the period 1996-2006. For all cases, indices of nutritional measurements were recorded retrospectively. Mann-Whitney U test was used for statistical analysis. A value of p<0.05 was considered significant. Results: The mean ages were 59.3±12.6 and 58.1±11.9 years in the enteral and total parenteral nutrition groups, respectively. Of all patients, 60 (76.8%) were male and 18 (23.2%) were female. Enteral nutrition was received by 32 (41.0%) patients for 9.5±5.7 days, and total parenteral nutrition was received by 46 (59.0%) patients for 10.7±6.4 days (p=0.146). In the enteral nutrition group, 12 (37.5%) patients were severely malnourished as defined by the Subjective Global Assessment, while in the parenteral nutrition group, this number was 15 (32.6%) (p=0.096). Ig G and Ig A values were higher in the enteral nutrition group (p=0.001, p=0.036, respectively), while Ig M values did not differ between groups (p=0.079). Conclusions: Cases with stomach cancer receiving enteral or total parenteral nutrition, while showing no differences in anthropometric and biochemical parameters, demonstrated differences in immune system parameters in favor of enteral nutrition.
