Giris ve Amaç: Türkiye?de Helikobakter pilori prevalansi yaklasik %80?dir. Proton pompa inhibitörü, amoksisilin ve klaritromisinden olusan standard üçlü tedavi rejimi ile eradikasyon orani zamanla azalmaktadir. Eradikasyon oranini arttirmak amaci ile bu rejimlere probiyotikler ve çesitli vitaminler eklenmistir. Bu çalismanin amaci 7 günlük standard üçlü tedaviye 14 gün süre ile C ve E vitamini eklenmesinin Helikobakter pilori eradikasyon oranini arttirip arttirmayacagini arastirmaktir. Gereç ve Yöntem: Bu çalismaya 53 Helikobakter pilori pozitif nonülser dispepsili hasta dahil edildi. Tüm hastalar 7 günlük lansoprazol 30 mg BID, amoksisilin 1000 mg BID ve klaritromisin 500 mg BID ile birlikte 14 günlük vitamin C 500 mg BID ve vitamin E 200 IU BID aldi. Eradikasyon oranlari intention-to-treat ve per-protocol analizleri ile hesaplandi. Bulgular: Elli hasta çalismayi tamamladi. Helikobakter pilori eradikasyonu intention-to-treat analizde 53 hastanin 31?inde (58,5%), per-protocol analizde 50 hastanin 31?inde(62%) saglandi. Sonuç: Bu çalismada elde edilen eradikasyon orani basarili olarak kabul edilen %80?in altinda olsa da daha önceki çalismalarda 7 günlük standard üçlü tedavi ile elde edilen oranlardan daha yüksektir. Tedaviye antioksidan C ve E vitaminlerinin eklenmesi eradikasyon oranini arttirmaktadir.
Background and Aims: In Turkey, the estimated prevalence of Helicobacter pylori infection is approximately 80%. The eradication rate has been decreasing over time with standard triple therapy regimens including a proton pump inhibitor plus amoxicillin plus clarithromycin. These regimens have been supplemented with probiotics and various antioxidants to increase the eradication rate. The aim of this study was to evaluate whether supplementation of the 7-day standard triple therapy with vitamins C and E for 14 days would increase the Helicobacter pylori eradication rate. Materials and Methods: This study included 53 patients with Helicobacter pylori-positive non-ulcer dyspepsia. All patients received lansoprazole 30 mg BID, amoxicillin 1000 mg BID, and clarithromycin 500 mg BID for 7 days, as well as vitamin C 500 mg BID and vitamin E 200 IU BID for 14 days. Eradication rates were calculated using both intention-to-treat and per-protocol analyses. Results: Fiftythree patients were analyzed using intention-to-treat analysis. Fifty patients completed the study. Helicobacter pylori eradication was achieved in 31 (58.5%) of the 53 patients included in the intention-to-treat analysis and in 31 (62%) of the 50 patients included in the per-protocol analysis. Conclusions: Although this eradication rate is lower than the accepted 80% eradication rate, it is higher than eradication rates achieved in previous studies with 7-day standard triple therapy. Supplementation with antioxidants increases the eradication rate.