Nöroendokrin tümörler, nöroendokrin sistem hücrelerinden köken alan heterojen bir neoplazma grubundan olusmaktadirlar. Bu olgu sunumunda diffüz karaciger metastazi ile seyreden non-fonksiyone bir nöroendokrin tümör olgusu tartisilmistir. Klinigimize karin agrisi ve karinda sislik sikayetleri ile basvuran 62 yasindaki bayan hastanin yapilan ilk degerlendirmesinde masif hepatomegali saptandi. Laboratuar incelemelerinde hipertiroidi disinda anlamli bir bulgu bulunmadi. Radyolojik incelelemelerde ise karacigerde diffüz metastazla uyumlu çok sayida hipodens kitle lezyonlari saptandi. Yapilan karaciger biyopsisi, hepatik nöroendokrin tümör metastazi ile uyumlu bulundu. Hastada primer odak bulunamadi. Diffüz karaciger tutulumu birlikte hastanin yasinin ileri olmasi nedeni ile cerrahi rezeksiyon dusünülmedi. Hastaya uzun etkili somatostatin analogu baslandi. Takiplerde hastanin semptomlari gerilemesine ragmen radyolojik bulgularda gerileme gözlenmedi. Sonuç olarak nadir görülen nöroendokrin tümörlerin alisilageldigi yavas seyrinin aksine tümüyle yakin zamana kadar asemptomatik seyretmesine karsin, yaygin karaciger metastaziyla birlikte afonksiyone olarak prezente olabilecegi göz önünde bulundurulmalidir.
Neuroendocrine tumors arise from neuroendocrine system cells, and constitute a heterogeneous group of neoplasms. In this case report, a case of non-functional neuroendocrine tumor presented with diffuse liver metastases is discussed. In the initial evaluation, massive hepatomegaly was detected in a 62-year-old female admitted to our clinic due to symptoms of abdominal pain and bloating. There was no detectable abnormality except hyperthyroidism in the laboratory studies. Numerous hypodense mass lesions compatible with diffuse hepatic metastases were found in radiological examinations. Liver biopsy showed neuroendocrine tumor in hepatic metastases. No focus was found for the primary site of tumor. Surgical resection as a treatment option was not applicable because of her advanced age and diffuse liver metastases. Long-acting somatostatin analogue was prescribed for the patient. In the follow-up, despite reduction in the patient's symptoms, there was no change in the tumor size. In conclusion, it should be kept in mind that rare neuroendocrine tumors may present with asymptomatic diffuse liver metastases with a non-functional tumor, despite the fact that these tumors have an indolent course.