Elazig kent toplumunda nonalkolik yagli karacigerin epidemiyolojik özellikleri
Epidemiologic features of nonalcoholic fatty liver in urban community of Elazig
Özet
Giris ve amaç: Endüstri toplumlarinda nonalkolik yagli karacigere sik rastlanmaktadir. Türkiye’de ise NAYK’in epidemiyolojik verileri yetersizdir. Bu çalisma bir Dogu Anadolu genel popülasyon örneginde ultrasonografi ile saptanmis Nonalkolik yagli karaciger sikligini ve risk faktörlerini belirlemek amaciyla yapilmistir. Gereç ve yöntem: Elazig sehir merkezinden randomize seçilen 459 kisiye hepatobiliyer ultrasonografi yapildi. Bireylerin vücut kitle indeksleri, bel çevreleri, kan lipidleri, glukoz, hepatit serolojisi ve transaminaz seviyeleri ölçüldü. Istatistik analiz SPSS 13.0 programinda ki kare, t-testi ve lojistik regresyon testleri kullanilarak yapildi. Bulgular: Çalismaya yaslari 18-80 arasinda degisen 408 kisi katildi. Düzenli alkol kullanan bir ve kronik viral hepatiti olan üç kisi çikarildiktan sonra kalan 404 kisi degerlendirildi. Nonalkolik yagli karaciger sikligi kadinlarda %16.5, erkeklerde %23.7 (p<0.05), toplam %19.8 bulundu. Nonalkolik yagli karaciger sikligi besinci dekatta en yüksekti ve 40 yas altinda, erkeklerde kadinlardan iki kat daha yüksekti (p<0.05). Nonalkolik yagli karaciger ve vücut kitle indeksi, bel çevresi, serum alanin aminotransferaz (ALT), açlik kan sekeri ve trigliserid seviyeleri arasinda anlamli iliski bulundu. Lojistik regresyon analizi kadinlarda bel çevresi ve ileri yasin, erkeklerde bel çevresi ve artmis ALT seviyesinin nonalkolik yagli karaciger için bagimsiz belirleyiciler oldugunu gösterdi. Sonuç: Nonalkolik yagli karaciger toplumumuzun beste bir kadarini etkileyen yaygin bir hastaliktir ve genç erkeklerde daha siktir. Ülkemizde santral obezite No
Abstract
Background/aim: Nonalcoholic fatty liver disease is common in industrialized societies, but epidemiological data of nonalcoholic fatty liver disease is insufficient in Turkey. The aim of this study was to determine the prevalence of nonalcoholic fatty liver disease diagnosed by ultrasonography and the risk factors in an eastern Turkish general population. Materials and methods: A hepatobiliary ultrasonography was performed on 459 subjects randomly selected from the general population in Elaz›g. Body mass index and waist circumference were calculated and serum lipids, glucose, viral serology and aminotransferases levels were measured. In statistical analysis, chi-square, t-test and logistic regression were used. Results: 408 subjects ranging in age from 18 to 80 years participated in the study. After four persons were excluded (1 for regular alcohol consumption and 3 for chronic viral hepatitis), the remaining 404 persons were evaluated. Prevalence of Nonalcoholic fatty liver disease was 16.5% in females, 23.7% in males (p<0.05), and 19.8% in all subjects. Nonalcoholic fatty liver disease was most frequent in the fifth decade, and more common in males than females under 40 years (p<0.05). There was a significant association between nonalcoholic fatty liver disease and body mass index, waist circumference, serum ALT and triglyceride levels. Logistic regression analysis revealed that in females, waist circumference and advanced age, and in males, waist circumference and increased ALT are independent predictors of nonalcoholic fatty liver disease. Conclusion: Nonalcoholic fatty liver disease is a common disease that affects one-fifth of the Turkish population, and it is more common in young males especially. Central obesity seems an important factor for development of nonalcoholic fatty liver disease in our country.
