Multipl endokrin neoplazi Tip 1, 11. kromozomun uzun kolundaki defekte bagli olarak gelisen otozomal dominant kalitimli nadir görülen bir hastaliktir. Hastalarda pankreatik endokrin tümör, hipofiz bezinde adenom ve paratiroid bezinde adenom saptanabilmektedir. Pankreatik endokrin tümörler arasinda en sik gastrinomaya rastlanmakta (%60) ve hastalarin %20-25?inde görülmektedir. Gastrinoma sik tekararlayan üst gastrointestinal sistem kanamalarina neden olmaktadir. Sik tekrarlayan üst gastrointestinal sistem kanamasi nedeniyle yapilan incelemelerde gastrinoma saptanan multipl endokrin neoplazi Tip 1 hastasinin basarili tani ve tedavisi ile kalici kür elde edilebilmektedir. Biz sik tekrarlayan üst gastrointestinal kanama sonrasi gastrinoma komponentli multipl endokrin neoplazi Tip 1 multipl vakasi sunduk.
Multiple endocrine neoplasia type 1 is an uncommon autosomal dominant hereditary disease due to a defect on the long arm of chromosome 11. Pancreatic endocrine tumor and adenomas of the pituitary and parathyroid glands can be detected in these patients. Among the pancreatic endocrine tumors, gastrinomas are frequently detected (60%) and is seen in 25% of patients. Gastrinoma can be the cause of recurrent upper gastrointestinal system bleedings. In the evaluation of multiple endocrine neoplasia type 1 patients with frequent upper gastrointestinal system bleedings due to gastrinoma, permanent cure can be obtained with successful diagnosis and management. We report a case with multiple endocrine neoplasia type 1 who referred with frequent upper gastrointestinal bleeding due to gastrinoma.