Nisan 2009
Tek merkeze ait hepatosellüler karsinom verileri; retrospektif çalisma
Data of hepatocellular carcinoma from a single center: A retrospective study
- Ana Sayfa
- Sayılar
- Nisan 2009
- Tek merkeze ait hepatosellüler karsinom verileri; retrospektif çalisma...
Özet
Giris ve Amaç: Hepatosellüler karsinomla ilgili ülkemize ait veriler oldukça azdir. Bu nedenle, belirli zaman diliminde klinigimizde hepatosellüler karsinom tanisi ile takip edilen hastalara ve tümöre ait tanimlayici verileri sunmayi amaçladik. Gereç ve Yöntem: Klinigimizde 2000?2006 yillari arasinda hepatosellüler karsinom tanisi alan hastalara ait kayitlar tarandi. Bulgular: Hepatosellüler karsinomlu 98 hastanin %12,2?si kadin ve %87,8?i erkekti. Hastalarin yas ortalamasi 60,6±9,6 yildi. HBV pozitif hastalar HCV pozitif hastalara göre anlamli olarak daha gençti. Hastalarin %84,7?sinde karaciger sirozu vardi. Vakalarin %63,3?ünde HBV, %22,5?inde HCV, %5,1?inde alkol kullanimi vardi ve %5,1?inde kronik karaciger hastaligi etiyolojisi bulunamadi. Sirotik olgulari n %33,3?ü Child A, %39,5?i Child B ve %27,2?si Child C idi. Hastalari n %8,2?de portal ven trombozu tespit edildi. Serum alfa-fetoprotein düzeyi olgularin %30,6?da >200 ng/ml, %41,8?de <20 ng/ml ve %27,6?da 20?200 ng/ml arasinda bulundu. Hastalarin %54,1?de tek lezyon, %42,8?de ≥2 lezyon ve %3?de diffüz tip tespit edildi. Hastalarimi- zin %26,5?de <3 cm, %42,9?da 3-5 cm ve %26,5?de >5 cm büyüklügünde lezyon tespit edildi. Lezyonlar hastalarin %56,1?de sag lobda, %17,3?de sol lobda ve %26,5?de her iki lobda saptandi. Hastalarin %59,2?ne alkol ablasyon, %11,2?ne kemoembolizasyon, %4,1?ne cerrahi rezeksiyon uygulandi. Hastalarimizin %21,4?üne semptomatik tedavi, %2?sine sistemik kemoterapi ve %2?sine karaciger transplantasyonu yapi ldi. Sonuç: Hepatosellüler karsinom ileri yaslarda özellikle erkeklerde sik görülür ve hepatosellüler karsinom için ülkemizde halen viral etiyoloji, özellikle HBV en önemli risk faktörüdür.
Abstract
Background and Aims: There is a lack of information about hepatocellular carcinoma in Turkey. Therefore, we aimed to present the data regarding the tumor characteristics and records of patients followed for hepatocellular carcinoma in a specific time period. Materials and Methods: We retrospectively reviewed the records of our patients diagnosed as hepatocellular carcinoma between 2000 and 2006. Results: There were 98 patients (12.2% F, 87.8% M). The mean age of the patients was 60.6±9.6 years. HBV (+) patients were significantly younger than HCV (+) patients. Alcohol abuse was the etiological factor in 5.1% of the patients, and no etiologic cause could be identified in 5.1% of the patients. The distribution of the patients with cirrhosis was as follows: Child A, 33.3% of patients; Child B, 39.5% of patients; and Child C, 27.2% of patients. Portal vein thrombosis was found in 8.2% of the patients. Serum alpha-fetoprotein levels were as follows: >200 ng/ml in 30.6%, <20 ng/ml in 41.8% and 20?200 ng/ml in 27.6% of the patients. Liver cirrhosis was present in 84.7% of the patients. There was a single nodule in 54.1%, ?2 nodules in 42.8% and diffuse nodules in 3% of the patients. The tumor diameter was <3 cm in 26.5%, 3?5 cm in 42.9% and >5 cm in 26.5% of the patients. Nodules were localized in the right lobe in 56.2% and left lobe in 17.3%, and were bilateral in 26.5% of the patients. 59.2% of the patients were treated with alcohol ablation and 11.2% with chemoembolization. 4.1% of the patients received surgical therapy. 21.4% of the patients received symptomatic therapy, 2% systematic chemotherapy and 2% underwent liver transplantation. Conclusions: Hepatocellular carcinoma is usually seen in older male patients. Viral etiology, especially HBV, remains the most important etiological factor in our country.
