Nisan 2009
Endoskopik olarak tanimlanan gastrit ile histolojik bulgular arasindaki iliski
The relation between endoscopically diagnosed gastritis and its histologic findings
- Ana Sayfa
- Sayılar
- Nisan 2009
- Endoskopik olarak tanimlanan gastrit ile histolojik bulgular arasindaki iliski...
Özet
Giris ve Amaç: Gastrik mukozadaki diffüz makroskopik degisiklikler gastrit olarak yorumlanir. Gastritin makroskopik ve mikroskopik özellikleri arasinda her zaman yeterince bir iliski ortaya konulamamistir. Bu çalismamizda gastritli hastalarda endoskopik görünümler ile histolojik bulgular arasindaki iliskiyi ortaya koymayi amaçladik. Gereç ve Yöntem: Ocak 2004 ile Mart 2005 tarihleri arasinda dispeptik yakinmalar nedeni ile özofagogastroduodenoskopi yapilan ve gastrit saptanan 131 hasta çalismaya dahil edildi. Endoskopik olarak saptanan gastrit bulgulari Sidney siniflamasina göre yapildi. Standart büyüklükte biyopsi forsepsi kullanilarak antrum ve korpustan ikiser adet biyopsiler alindi. Histopatolojik degerlendirme gastrointestinal sistem patolojisinde deneyimli patologlar tarafindan Sidney Sistemine göre yapildi. Bulgular: Korpusda endoskopik olarak saptanan eritemin tipleri ile korpustan alinan biyoside Helikobakter pilori (p=0.031), atrofi (p=0.000) ve aktivasyon saptanmasi arasinda istatistiksel olarak anlamli bir iliski vardi. Ayni zamanda endoskopik olarak korpusda ödem saptanmasi ile histolojik olarak korpusda Helikobakter pilori saptanmasi arasinda istatistiksel olarak anlamli bir iliski vardi (p=0.03). Antrumda endoskopik olarak eritem gözlenmesi ile antrumdan alinan biyopsi örneklerinde enflamasyon (p=0.24), Helikobakter pilori varligi (p=0.29), atrofi (p=0.72), aktivite (p=0.57) ve metaplazi (p=0.76) saptanmasi arasinda anlamli bir iliski saptanmadi. Sonuç: Korpusda eritemin gözlenmesi histolojik olarak Helikobakter pilori gastriti, aktivite ve atrofinin varligini gösteren önemli bir belirteçtir.
Abstract
Background and Aims: Gastritis refers to macroscopic changes in the gastric mucosa. A correlation between macroscopic and microscopic features of gastritis has not yet been adequately established. In this study, we aimed to expose the relationship between endoscopic appearance and histological findings in gastritis patients. Materials and Methods: One hundred thirty-one patients who had upper gastrointestinal system endoscopy for dyspepsia between January 2004 and March 2005 were enrolled in this study. Endoscopic classification of gastritis was performed according to the Sydney system. Two samples from both antrum and corpus were obtained by standard size biopsy forceps. Histological examination was performed by an expert gastrointestinal pathologist according to the Sydney system. Results: There was a statistically significant relation between endoscopic erythematous appearance of the corpus and presence of Helicobacter pylori (p=0.031), atrophy (p=0.000) and activation (p=0.001). There was also a statistically significant relation between endoscopic edematous appearance and histological presence of Helicobacter pylori (p=0.03). There was no statistically significant relation between endoscopic erythematous appearance of the antrum and presence of inflammation (p=0.24), Helicobacter pylori (p=0.29), atrophy (p=0.72), activation (p=0.57), or metaplasia (p=0.76). Conclusions: The appearance of erythema in the corpus is a valuable marker for the histological presence of Helicobacter pylori gastritis, activity and atrophy.
