Giris ve Amaç: Bu deneysel çalismada siçanlarda gelistirilen akut koroziv özofajit modelinde tek basina pentoksifilinin ve pentoksifilin+trimetazidin kombinasyonunun birlikte kullaniminin striktür olusumunu önleyici etkisi arastirilmistir. Gereç ve Yöntem: 48 siçan dört gruba ayrilmi stir. Distal özofagusa 90 saniye süreyle %37.5 NaOH uygulanmasi ve ardindan serum fizyolojik ile yikanmasiyla koroziv özofajit modeli olusturulmustur. Gruplar sirasiyla; Grup A 1 ml/gün serum fizyolojik, Grup B tedavisiz, Grup C pentoksifilin 50 mg/kg/gün, Grup D pentoksifilin (50mg/kg/gün) ve trimetazidin (5 mg/kg/gün) olacak sekilde uygulama yapildi. 28 gün intraperitoneal uygulamaya devam edildi. Özofagus duvar kalinligi, stenoz indeksi, histopatolojik hasar skoru ve dokuda hidroksiprolin düzeyi incelendi. Bulgular: Pentoksifilin tek basina kullanildi ginda özofagus duvar kalinligi ve stenoz indeksini degistirmemesine karsin doku OH-prolin düzeyini azaltmaktadir. Deneysel kosullarda pentoksifilin ile birlikte kullanilan trimetazidinin striktür önleyici etkileri sadece pentoksifilin kullanimindan daha üstün bulundu. Dokudaki inflamasyonun indirekt göstergesi olan duvar kalinligi açisindan incelendiginde C ve D gruplari arasindaki fark anlamliydi. Stenoz indeksi yönünden tedavisiz birakilan grupla C ve D gruplari arasindaki anlamli fark olmasi zaten beklenen sonuçtur. Ancak C ve D gruplari arasindaki sonuç da istatistiksel olarak anlamliydi. En yüksek doku hidroksiprolin degerleri beklendigi üzere tedavisiz birakilan grupta saptandi. Sonuç: Pentoksifilin ile birlikte kullanilan trimetazidin tek basina pentoksifilin kullanimina göre koroziv maddeye bagli özofagus hasari ve striktürü önleme açisindan daha yararli oldugu deneysel ortamda saptanmistir.
Background and Aims: In this experimental study, the preventive effects of pentoxifylline alone and of pentoxifylline+trimetazidine combination in strictures due to a corrosive esophagitis model in rats were investigated. Materials and Methods: Forty-eight rats were randomly divided into four groups. Corrosive esophagitis was induced in all groups by application of 37.5% NaOH to the distal esophagus for a period of 90 seconds followed by saline rinse. The groups of animals and treatment protocols were as follows: Group A: only saline 1 ml/day, Group B: no treatment, Group C: pentoxifylline 50 mg/kg/day, and Group D: pentoxifylline (50 mg/kg/day) + trimetazidine (5 mg/kg/day), administrated for 28 days intraperitoneally. The efficacy of treatment was assessed in groups by measuring wall thickness of the esophagus, stenosis index, histological evaluation criteria, and biochemical determination of tissue hydroxyproline content. Results: At the end of the study, in the pentoxifylline- treated group (Group C), although wall thickness of the esophagus and stenosis index were not affected, tissue hydroxyproline content was reduced. In vitro conditions and stricture-prevention effects of pentoxifylline+trimetazidine combination were more prominent when compared to pentoxifylline treatment alone. Evaluation of wall thickness measurements, which is an indirect indicator of tissue inflammation, demonstrated statistically significant differences between Groups C and D. A meaningful difference in the stenosis indexes between Group B and each treatment group (Groups C and D) was a natural consequence as expected. Nevertheless, differences related to stenosis index between Groups C and D were also significant. The highest level of hydroxyproline was detected in the no treatment group (Group B), as expected. Conclusions: In the experimental model, administration of trimetazidine in combination with pentoxifylline revealed that combination of these drugs was more effective than pentoxifylline administration alone in the prevention of esophageal injury and strictures due to corrosive materials.