Aralik 2008
Ülseratif kolitli hastalarda tiroid hormon bozukluklari
Thyroid hormon levels in ulcerative colitis patients
- Ana Sayfa
- Sayılar
- Aralik 2008
- Ülseratif kolitli hastalarda tiroid hormon bozukluklari...
Özet
Giris ve Amaç: Kronik inflamatuvar barsak hastaliklari (Ülseratif kolit ve Crohn Hastaligi)’nin da safra yollari, eklem ve göz gibi sistemik tutulum gösterdigi bilinmektedir. Son zamanlarda ülseratif kolit ile tiroid hastaliklari arasinda iliskiyi gösteren olgu sunumlari ve az sayida klinik çalisma yayinlanmistir. Biz de bu çalismada ülseratif kolit hastalarinda tiroid hormon düzeylerini arastirmayi amaçladik. Gereç ve Yöntem: Klinigimizde 2004-2007 tarihleri arasinda ülseratif kolit tanisi konan 25 hasta ve ülseratif kolit olmayan 32 saglikli kontrol çalismaya alindi. Hastalar yas, cinsiyet, ülseratif kolit tutulum yeri, aktivasyon, hastalik süresi gibi parametreler açisindan degerlendirildi. Bulgular: Ülseratif kolit tanisi almis toplam 25 hastanin 12’si kadin, 13’ü erkek ve yas ortalamalari sirasi ile; 31.75±14.23 ve 34±9.40 idi. Kontrol grubunun ise 19’u kadi n, 13’ü erkek ve yas ortalamalari sirasi ile 34.52±10.16 ve 34.53±9.99 saptandi. Her iki grupta serbest T3 ve T4 düzeyleri normal saptandi. TSH düzeylerine göre degerlendirildiginde çalisma grubunda 2 subklinik hipertiroidi (%8) saptanirken kontrol grubunda 2 subklinik hipertiroidi (%6) ve 1 subklinik hipotiroidi (%3) tespit edildi. Fakat bu oranlar arasi nda istatistiksel fark saptanmadi. Sonuç: Daha fazla hasta grubu ile otoantikorlarin da degerlendirildigi çalismalara ihtiyaç oldugu kanisindayi z.
Abstract
Background and aims: Chronic inflammatory bowel diseases (ulcerative colitis and Crohn) are also known to exhibit systemic involvement such as in the biliary system, joints and the eyes. Recently, case reports and a few clinical investigations were released demonstrating the relationship between ulcerative colitis and thyroid diseases. We aimed to investigate thyroid hormone levels in patients with ulcerative colitis in this study. Materials antd Methods: Twenty-five patients diagnosed as ulcerative colitis between 2004-2007 in our clinic and 32 healthy controls without ulcerative colitis were included in the study. The patients were evaluated with respect to the parameters of age, gender, site of involvement of ulcerative colitis, duration of the disease and its activation. Results: Of the total 25 ulcerative colitis patients, 12 were women, 13 were men and their mean ages were 31.75 ± 14.23 and 34 ± 9.40, respectively. The control group included 19 women and 13 men (mean ages: 34.52 ± 10.16 and 34.53 ± 9.99, respectively). The levels of FT3 and FT4 were detected as normal in both groups. When evaluated according to thyroid stimulating hormone levels, two (8%) subclinical hyperthyroidism cases were diagnosed in the study group, and two (6%) subclinical hyperthyroidism and one (3%) subclinical hypothyroidism cases were detected in the control group. However, no statistical difference was found between these rates. Conclusions: In conclusion, further studies with larger patient numbers that also evaluate autoantibodies are essential.
