Agustos 2008
Özofageal melanositozis - Üç olgu ve literatürün gözden geçirilmesi
Esophageal melanocytosis - Three cases and review of the literature
- Ana Sayfa
- Sayılar
- Agustos 2008
- Özofageal melanositozis - Üç olgu ve literatürün gözden geçirilmesi...
Özet
Endoskopik özofageal melanositozis özofagus squamöz epitel bazal tabakasinda melanositik proliferasyon ve özofagus mukozasinda melanin miktarinda artis ile karakterize benign, nadir görülen klinik ve patolojik bir durumdur. Melanozis olarak da adlandirilir. Her ne kadar gastroözofageal reflü hastaliginin ve diger mukozal hasar ve keratinositik hiperplazinin sonucu olabilecegi hipotezi ileri sürülse de etyoloji ve patogenezi ile ilgili bilgiler azdir. Ayirici tanisi melanositik nevüs ve malign melanomu içerir. Primer özofageal melanomani n prekürsörü olabilecegi ileri sürülse de ileri arastirmalar gerekmektedir. Nadir oldugundan spesifik semptom ve spesifik tedavi raporu yoktur. Biz nadir görülen özofageal melanositozisli üç olguyu sunduk ve literatürü gözden geçirdik
Abstract
Endoscopic or macroscopic esophageal melanocytosis is a benign, rare clinic and pathologic condition characterized by melanocytic proliferation in the basal layer of esophageal squamous epithelium and an increased amount of melanin in the esophageal mucosa. Esophageal melanocytosis is also called melanosis. Little is known about the etiology and natural course of this condition, although it has been suggested that esophageal melanocytosis may be a result of gastroesophageal reflux disease or other chronic stimuli that cause mucosal damage and keratinocytic hyperplasia. Differential diagnosis of esophageal melanocytosis includes benign melanocytic nevi and malignant melanoma. Although it has been suggested to be a precursor of primary esophageal melanocytosis, this awaits further investigations. Because esophageal melanocytosis is rare, there has been no report of esophageal melanocytosis that resulted in specific symptoms or special treatments. We present three patients with esophageal melanocytosis and review the literature.
