Nonülser dispepside Helikobakter pilori sikligi ve eradikasyon tedavisine yanit
The prevalance of Helicobacter pylori in nonulcer dyspepsia and response to the eradication therapy
- Ana Sayfa
- Sayılar
- Nonülser dispepside Helikobakter pilori sikligi ve eradikasyon tedavisine yanit...
Özet
Giris ve amaç: Nonülser dispepsi etyolojisi net olarak bilinmeyen ve birçok faktörün neden olarak öne sürüldügü bir hastaliktir. H. pilori de suçlanan faktörlerden biridir. Amacimiz nonülser dispepsi ile H. pilori arasindaki ilisikiyi ve eradikasyona yaniti arastirmaktir. Gereç ve yöntem: Bu çalismada, 24’ü kadin 20’si erkek olmak üzere 44 nonülser dispepsi hastasi (yas ort. 34,36 ± 13,08) yer almistir. Kontrol grubu olarak 15 kisilik asemptomatik vaka ( 6 bayan, 9 erkek, yas ortalamasi 32,06 ± 15,09) alinmistir. Bulgular: Nonülser dispepsi tanili çalisma hastalarda üreaz testi ile H. pilori varligi % 56,8 saptanmistir. Kontrol grubunda ise %20 saptanmistir. Nonülser dispepsili hastalari ülser benzeri, dismotilite benzeri ve reflü benzeri alt gruplara ayirdigimizda, üreaz testi ile H. pilori pozitifligi, sirasiyla % 61,9, %50,0 ve %55,5 olarak tespit edilmistir. Üreaz testi ile H. pilori pozitifligi saptanan 27 kisiye eradikasyon tedavisi baslanmistir. Ilaçlarini düzenli kullanarak tedavi bitiminden 6 hafta sonra kontrole gelen 11 hastaya üre nefes testi uygulanmistir. Üre nefes testi ile 5 hastada (%45, 45) infeksiyonun eradike edildigi gösterildi. Bu 5 hastadan 3’ünde, ilk basvurudaki sikayetler devam etmekteydi. Eradikasyonun saglanamadigi 6 hastada ilk basvurudaki sikayetleri devam ettigi saptandi. Eradikasyon tedavisi 11 vakadan 2’sinde (%18,1) yüz güldürücü sonuca ulasmistir. Sonuç: Nonülser dispepside H. pilori sikligi kontrol grubuna göre yüksek bulunmustur, ancak H. pilori eradikasyonu yararli bulunmamistir.
Abstract
Background/aim: The etiology of nonulcer dyspepsia is unknown and many factors are suspected. H. pylori is one of the most often accused factors. Our aim was to research the frequency of H. pylori in nonulcer dyspepsia patients and to determine whether H. pylori is more frequent in nonulcer dyspepsia patients than in asymptomatic patients. We also evaluated the symptomatic improvement in H. pylori-positive patients. Materials and methods: 44 nonulcer dyspepsia patients (24 F, 20 M; mean age: 34.36 ± 13.08) were included in the study. 15 asymptomatic individuals (6 F, 9 M; mean age: 32.06 ± 15.09) were included as a control group. Results: H. pylori positivity was 56.8% according to urease test in nonulcer dyspepsia patients, and 20% in the control group. When we classified nonulcer dyspepsia patients to subgroups as ulcer-like, dysmotility-like and reflux-like, H. pylori positivity was 61.9%, 50% and 55.5%, respectively. Eradication therapy was applied to 27 H. pylori- positive patients in whom positivity was established by means of the urease test. Urea breath test was applied to 11 patients 6 weeks after the end of therapy. It was established that infection was eradicated in 5 patients (45.5%). Complaints were continuing in 6 patients in whom eradication was not achieved. Successful results were achieved in 2 of 11 (18.1%) patients by means of eradication therapy. Conclusion: The H. pylori prevalence is higher in patients with nonulcer dyspepsia than in healthy controls, but H. pylori eradication therapy is not useful.
