Helicobacter pylori pozitif ve negatif hastalarda intestinal metaplazi ve displazi sikligi
The frequency of intestinal metaplasia and dysplasia among Helicobacter pylori positive and negative patients
- Ana Sayfa
- Sayılar
- Helicobacter pylori pozitif ve negatif hastalarda intestinal metaplazi ve displazi sikligi...
Sütçü Imam Üniversitesi Tip Fakültesi, Gastroenteroloji Anabilim Dali2, Genel Cerrahi Anabilim Dali3, Kahramanmaras
Özet
Giris ve amaç: Rutin üst gastrointestinal endoskopi için refere edilen H. pylori pozitif ve negatif dispeptik hastalarda intestinal metaplazi ve displazi sikligini karsilastirmak. Gereç ve yöntem: 141 dispeptik hasta çali- sildi (Yas ortalamasi 44.7+16 yil, yas araligi 16-87 yil, 62 erkek ve 79 kadin). Histolojik olarak H. pylori, intestinal metaplazi ve displazinin saptanmasi için antrum ve korpustan biyopsiler alindi. Bulgular: 141 hastanin 96’si (%68.1) H. pylori pozitif idi. Intestinal metaplazi ve displazi sirasiyla H. pylori pozitif hastalarin %42.7 (41/96) ve %5.2’sinde (5/96) ve H. pylori negatif hastalarin %37.7 (17/45) ve %4.4’ünde (2/45) bulundu (p>0.05). Intestinal metaplazisi olan hastalarin %70,7’si (41/58) ve displazisi olan hastalarin %71.4’ü (5/7) H. pylori pozitif idi (p>0.05). Sonuç: H. pylori pozitif ve negatif hastalar arasinda intestinal metaplazi ve displazi sikligi yönünden istatistiksel olarak anlamli farklilik yoktu, ancak intestinal metaplazisi ve displazisi olan hastalardaki yüksek orandaki H. pylori varligi dikkat çekiciydi.
Abstract
Background/aim: To compare the frequency of intestinal metaplasia and dysplasia in H. pylori-positive and negative dyspeptic patients referred for routine upper gastrointestinal endoscopy. Materials and methods: One hundred and forty-one dyspeptic patients were studied (average age 44.7+16 years, range 16-87 years, 62 males and 79 females). Antrum and corpus biopsies were taken for detection of H. pylori, intestinal metaplasia and dysplasia histologically. Results: There were 96 H. pylori-positive patients in 141 patients (68.1%). Intestinal metaplasia and dysplasia were found in 42.7% (41/96) and 5.2% (5/96) among the H. pylori-positive patients and in 37.7% (17/45) and 4.4% (2/45) among the H. pylori-negative patients, respectively (P>0.05). 70.7% (41/58) of the patients with intestinal metaplasia and 71.4% (5/7) of the patients with dysplasia were H. pylori- positive, respectively (P>0.05). Conclusions: There was no statistically significant difference in the frequency of intestinal metaplasia and dysplasia between the patients who were H. pylori-positive and –negative, but the high ratio of H. pylori among the patients with intestinal metaplasia and dysplasia warrants attention.
