Granülamatoz gastritisli alti olgunun klinikopatolojik analizi
The clinicopathological analysis of six patient with granulomatous gastritis
Özet
Mide biyopsi örneklerinde granülomlarin görülmesi çok nadir olup, özellikle gelismis ülkelerde olgularin yaridan fazlasi Crohn hastaligi, sarkoidoz, Wegener granülomatozis gibi degisik nedenlerle iliskilidir. Izole granülomatöz gastritis tanisi granülomatöz hastalik yapan diger nedenler ekarte edildiginde verilmelidir. Biz granülamatöz gastritli alti olguyu sunduk. Bizim olgularimizda klinik olarak Crohn hastaligi, sarkoidoz, tüberküloz saptanmadi, bes olgu da mide mukozasinda Helikobakter pylori saptandi. Bir olgu ise izole granülamatoz gastritis olarak kabul edildi. Granülomlarin çogu antrum ve korpus yerlesimliydi. Granülamatoz gastritis tanisi morfolojik bulgular, klinik ve laboratuvar bilgiler temelinde verilmelidir. Bizim serimizdeki gibi fazla siklikta Helikobakter pylori saptanmasi etyolojide Helikobakterin rol oynayabilecegini düsündürmektedir.
Abstract
Granulomas in gastric biopsy specimens are extremely rare, and in developed countries, more than half are associated with different causes such as Crohn’s disease, sarcoidosis and Wegener’s granulomatosis. The diagnosis of isolated granulomatous gastritis is established only after exclusion of other organic granulomatous disease. We report six cases of granulomatous gastritis. Five were positive for Helicobacter pylori. No other causes of granulomatous gastritis could be found. In one case an isolated granulomatous gastritis was diagnosed. The granulomas were mainly found in the antrum and corpus. The final diagnosis of granulomatous gastritis is based on morphological findings and clinical and laboratory data. Because of the high incidence of Helicobacter pylori detected in granulomatous gastritis, Helicobacter pylori can be causal in its pathogenesis.
