Tip II Diabetes Mellituslu hastalarda Helicobacter pylori prevalansi
The prevalance of Helicobacter pylori in Type II Diabetes Mellitus patients
Özet
Giris ve amaç: Hp dünyada en sik rastlanan ve enfekte olgularda antrum agirlikli kronik gastrite neden olan bakteriyel bir etkendir. DM artmis enfeksiyon riskiyle karakterize metabolik bir hastaliktir. Bu nedenle çalismada DM’lu hastalarda Hp prevalansini, bu hastalarin metabolik durumu ve diabetin komplikasyonlari ile iliskisinin arastirilmasi amaçlandi. Gereç ve yöntem: Çalismaya dispeptik yakinmalari olan, tip 2 DM’lu 40 hasta, kontrol grubuna ise non-diabetik, dispeptik yakinmalari olan saglikli 28 olgu dahil edildi. Hastalar DM komplikasyonu ve metabolik kontrol yönünden degerlendirildi. Her iki gruba da üst gastrointestinal sistem endoskopisi uygulandi. Hp’nin histopatolojik tanisi ve patolojik inceleme yönünden mide korpus ve antrumundan 2’ser adet biyopsi alindi. Bulgular: Yas ve cins açisindan DM’lu ve kontrol grubu arasinda istatistiksel olarak anlamli bir fark yoktu. Hp varligi ile tip 2 DM, metabolik parametreler, glisemik kontrol, DM’un süresi ve komplikasyonlari arasinda istatistiksel olarak anlamli bir iliski saptanmadi. Endoskopik ve histopatolojik olarak antral gastrit ve kronik aktif gastrit görülme sikligi DM grubunda anlamli olarak yüksek bulunurken, kontrol grubunda eroziv duodenit anlamli olarak fazla saptandi. Sonuç: Elde ettigimiz bulgular Hp enfeksiyonu ile Tip 2 DM arasinda bir baglanti yi desteklememektedir. Bununla birlikte, guruplar arasinda gastritin tipleri açisindan anlamli fark saptanmasi, diabetik hastalarda gastritin degisik tipleri ve Hp prevalansi ile ilgili yeni çalismalarin gerekli oldugunu düsündürmektedir.
Abstract
Background/aim: Helicobacter pylori is the most common seen infectious agent in the world and causes life-long chronic gastritis, predominantly antral, in all carriers without exception. Diabetes mellitus is a disease characterized by a high risk for infections. Therefore, in this study we aimed to evaluate the prevalence of Helicobacter pylori in patients with diabetes mellitus, the metabolic status of these patients and the relation to the complications of diabetes. Materials and methods: Forty type 2 diabetes mellitus patients followed between August 2001- February 2002 by the Endocrinology Outpatient Clinic in Ataturk Training and Research Hospital, Izmir were included into the study. Twenty-eight non-diabetic patients with dyspeptic complaints served as the control group. Patients were evaluated with regard to diabetes mellitus complications and metabolic control. Upper gastrointestinal tract endoscopy was performed in both groups. For the histopathologic diagnosis and pathologic investigation of Helicobacter pylori, biopsies were taken from corpus and antrum. Results: There were no significant differences between the two groups concerning age and gender. No significant relation was found between Helicobacter pylori and type 2 diabetes mellitus, metabolic parameters, glycemic control duration and complications. Antral gastritis and chronic active gastritis were found to be significantly more frequent in the diabetes mellitus group, both endoscopically and histopathologically, and erosive duodenitis was found to be significantly more frequent in the control group. Conclusion: Our results do not support a relation between Helicobacter pylori and type 2 diabetes mellitus. However, the significant difference between the types of gastritis seen in the two groups suggests the need for further researches on gastritis in diabetic patients and Helicobacter pylori prevalence.
