Kronik pankreatit: 53 olgunun irdelenmesi
Chronic pancreatitis: Analysis of 53 cases
Özet
Giris ve amaç: Kronik pankreatit pankreasin ilerleyici, geri dönüsümsüz kalici fonksiyon bozuklugu ile karakterize inflamatuvar bir hastaligidir. Kronik pankreatit ile ilgili ülkemizde yayimlanmis genis kapsamli seriler yetersizdir. Bu makalede 53 kronik pankreatitli olgunun retrospektif olarak irdelenmesi amaçlanmistir. Gereç ve yöntem: Gastroenteroloji kliniginde Ocak 1998-Haziran 2003 tarihleri arasinda izlenen 53 olgu retrospektif olarak degerlendirilmistir. Olgular etyoloji, klinik, laboratuvar ve komplikasyon açisindan degerlendirilmistir. Bulgular: 53 olgunun 42’si erkek, 11’i kadin olup ortalama yas 52 (29-80)’dir. Olgularin %71,7’si karin agrisi, %17’si kilo kaybi, %7,5’i ishal, %3,8’si sarilik yaki nmalari ile basvurmustur. Olgularin %50’sinde kronik pankreatit için etyolojik faktör saptanamamis olup, %50’sinde ise etyolojik faktör olarak kronik alkol kullanimi saptanmistir. ERCP yapilan olgular Cambridge siniflamasina göre degerlendirildiginde, olgularin %11,5’i grade 1, %40’i grade 2 ve %48,5’i de grade 3 olarak saptanmistir. Olgularin %15’ine diyabetes mellitus saptanmis, %35’inde komplikasyonlar nedeniyle cerrahi tedavi gerekmistir. Sonuç: Kronik pankreatit erkeklerde sik görülen, baslica alkolizmin neden oldugu bir hastaliktir. Önemli bir kismi nda hala etyolojik bir neden saptanamamaktadir.
Abstract
Background/aim: Chronic pancreatitis is a progressive, destructive and irreversible inflammatory disease of the pancreas. In our country, studies including large series of patients with chronic pancreatitis are insufficient. The aim of this article was to retrospectively evaluate 53 patients with chronic pancreatitis. Materials and methods: The medical reports of 53 patients who were hospitalized in the Gastroenterology Department between January 1998-June 2003 and diagnosed as chronic pancreatitis were reviewed retrospectively. Patients were analyzed regarding etiology, clinical and laboratory findings and complications. Results: The median age of the 53 patients (42 males, 11 females) was 52 years (range: 29-80). The symptoms at admittance were abdominal pain (71.7%), weight loss (17%), steatorrhea (7.5%), and jaundice (3.8%). Etiology was chronic alcohol consumption in 50% of patients, and undetermined in 50%. The patients who underwent ERCP were classified according to Cambridge classification as grade 1 (11.5%), grade 2 (40%), and grade 3 (48.5%). Eight (15%) patients were diagnosed as diabetes mellitus, and 18 (35%) patients underwent surgery because of complications. Conclusion: Chronic pancreatitis is mainly caused by chronic alcoholism and dominantly diagnosed in male patients. Establishment of the etiology of chronic pancreatitis remains a challenge in many patients.
