Giris ve amaç: Kolesistektomi semptomatik safra taslari için standart tedavi olmasina ragmen duodenogastrik reflüyü indükleyen anotomik ve fonksiyonel degisikliklere yol açabilir. Bu çalismanin amaci kolesistektomi ile alkalen reflü, antral mukozal degisiklikler ve H. pylori kolonizasyonu arasindaki iliskiyi arastirmaktir. Gereç ve yöntem: Bu prospektif çalismaya 135 kolesistektomili (104 kadin, 31 erkek; 56.25±11.35 yil) ve 50 kontrol hastasi (35 kadin, 15 erkek; 55.48±12.50) alindi. Kolesistektomi geçiren grup kendi içerisinde kolesistektomi yilina göre siniflandi rildi (≤5 yil, 6-9 yil, 10 ≥). Tüm hastalara üst gastrointestinal endoskopi yapilarak alkalen reflü gastrit varligi degerlendirildi. Antrumdan ali- nan endoskopik biyopsilerde mukozadaki histopatolojik degisiklikler ve H. pylori varligi arastirildi. Bulgular: Alkalen reflü gastrit kolesistektomi grubunda (%58.5) kontrol grubuna (%6) göre anlamli olarak yüksek saptandi. H. pylori, Intestinal metaplazi, kronik aktif gastrit, ve kronik atrofik gastrit açisindan iki grup arasinda anlamli farklilik yoktu. Yillara göre kolesistektomi grubu sniflandirilarak yapilan degerlendirmede alkalen reflü gastrit kolesistektomi gruplarinin tamaminda kontrol grubuna göre anlamli olarak yüksekti, ancak kolesistektomi gruplari arasinda anlamli farklilik yoktu. H. pylori, intestinal metaplazi, kronik aktif gastrit ve kronik atrofik gastrit açisindan kontrol ile kolesistektomi gruplari arasinda ve kolesistektomi gruplarinin kendi arasinda istatistiksel olarak anlamli bir fark bulunmadi. Sonuç: Kolesistektomi endoskopik alkalen reflü gastrite yol açmakla beraber antrum mukozasinda histolojik degisiklere yol açmaz ve H. pylori kolonizasyonunu etkilemez.
Background/aim: Although cholecystectomy is the standard therapy for symptomatic gallbladder stones, it may lead to anatomic and functional changes that induce duodenogastric reflux. The aim of this study was to evaluate the relationship between cholecystectomy and alkaline reflux, antral mucosal changes, and colonization of Helicobacter pylori. Materials and methods: One hundred and thirty-five cases (104 female, 31 male; 56.25±11.35 years old) with cholecystectomy and 50 (35 female, 15 male; 55.48±12.50 years old) control cases were included in this prospective study. Patients with cholecystectomy were subclassified according to the time interval after cholecystectomy (≤5 years, 5-9 years, ≥10 years). All patients were investigated for alkaline reflux gastritis by upper gastrointestinal endoscopy. Mucosal histopathologic changes and Helicobacter pylori existence were evaluated in endoscopic biopsies obtained from the antrum. Results: Alkaline reflux gastritis in the cholecystectomy group (58.5%) was significantly higher than in the control group (6%). There was no significant difference between groups regarding to Helicobacter pylori existence, intestinal metaplasia, chronic active gastritis and chronic atrophic gastritis. Presence of alkaline reflux gastritis was significantly higher in all cholecystectomy subgroups than in the control group, but there were no significant differences between values among cholecystectomy subgroups. Rates of Helicobacter pylori, intestinal metaplasia, chronic active gastritis and chronic atrophic gastritis were similar between the control group and cholecystectomy subgroups and also among cholecystectomy subgroups. Conclusion: Cholecystectomy often leads to endoscopic alkaline reflux gastritis. Nevertheless, it does not influence Helicobacter pylori colonization nor cause antral mucosal histopathological changes.