ÖZET • Giris ve Amaç: Helicobacter pylori enfeksiyonunun farkli kliniklerine sahip hastalarda plazma paraoksonaz-1 seviyelerini ve oksidatif stres belirteçlerini karsilastirmak. Gereç ve Yöntem: Dispeptik semptomlari olan ve üst gastrointestinal sistem endoskopisi için yönlendirilen hastalar çalismaya dahil edildi ve Helicobacter pylori enfeksiyonu varligina göre gruplandirildi. Hizli üreaz testi pozitif olan hastalarda Helicobacter pylori eredike edildi. Paraoksonaz-1 düzeyleri ve oksidatif stres belirteçleri, Helicobacter pylori pozitif olup duodenal ülseri olan ve olmayan grup ve Helicobacter pylori negatif olan gruplar arasinda ve tedavi edilen hastalarda eradikasyon öncesi ve sonrasinda karsilastirildi. Bulgular: Çalis- maya 189 hasta dahil edildi. 82 hastada duodenum ülseri olmadan Helicobacter pylori pozitif, 49 hastada duodenum ülseri varken Helicobacter pylori pozitif, 58 hastada Helicobacter pylori negatifti. Kadinlarda paraoksonaz-1 düzeyleri degerlendirildiginde gruplar arasinda istatistiksel olarak anlamli bir fark bulunmazken, Helicobacter pylori negatif hastalarin degerleri erkeklerde diger 2 gruba göre istatistiksel olarak anlamli derecede yüksekti. Helicobacter pylori negatif hastalarda total antioksidan kapasitesi düzeyleri her iki cinsiyette de diger 2 gruba göre istatistiksel olarak anlamli derecede yüksekti. Helicobacter pylori enfeksiyonunun basarili bir sekilde ortadan kaldirilmasiyla total antioksidan kapasitesi ve paraoksonaz-1 düzeylerinde istatistiksel olarak anlamli bir artis oldu. Sonuç: Helicobacter pylori enfeksiyonu olan hastalarda plazma paraoksonaz-1 ve total antioksidan kapasitesi azalirken total oksidatif durum ve oksidatif stres indeksi artti. Aterosklerotik hastaliklara daha yatkin olan erkeklerde farkliliklar daha belirgindi. Ayrica Helicobacter pylori enfeksiyonunun ortadan kaldirilmasiyla hem paraoksonaz-1 düzeyleri hem de total antioksidan kapasitesi önemli ölçüde artti.
ABSTRACT • Background and Aims: To compare the plasma paraoxonase-1 levels and oxidative stress markers in patients with different states of Helicobacter pylori infection. Materials and Methods: Patients with dyspeptic symptoms and referred for upper gastrointestinal system endoscopy were consequently included and grouped according to the presence of Helicobacter pylori infection. Helicobacter pylori was eradicated in patients with positive rapid urase test. Total antioxidant status, total oxidant status and oxidative stress index were calculated. Paraoxonase-1 levels and oxidative stress markers were compared between 3 groups and in treated patients before and after eradication. Results: One hundred eighty nine patients were included the study. In eighty two patients Helicobacter pylori were positive without the presence of duodenal ulcer, in 49 patients Helicobacter pylori were positive with the presence of duodenal ulcer and Helicobacter pylori were negative in 58 patients. In evaluation of paraoxonase-1 levels in women, there were not any statistically significant difference between groups but Helicobacter pylori negative patients had statistically significantly higher values than other 2 groups among men. Total antioxidant status levels were statistically significantly higher in both genders in Helicobacter pylori negative patients than other 2 groups. There were a statistically significant increase in total antioxidant status and paraoxonase-1 levels with the successful eradication of Helicobacter pylori infection. Conclusion: Plasma paraoxonase-1 and total antioxidant status were decreased while total oxidant status and oxidative stress index were increased in the patients with Helicobacter pylori infection. The differences were more prominent in males who are more prone to atherosclerotic diseases. Moreover, with the eradication of Helicobacter pylori infection, both paraoxonase-1 levels and total antioxidant status were increased significantly