Nisan 2024
Çölyak hastaliginda Helicobacter pylori enfeksiyonu sikligi
Frequency of Helicobacter pylori infection in celiac disease
- Ana Sayfa
- Sayılar
- Nisan 2024
- Çölyak hastaliginda Helicobacter pylori enfeksiyonu sikligi...
Ankara Üniversitesi Tip Fakültesi, 2Hematoloji Bilim Dali, Ankara
Özet
Giris ve Amaç: Helicobacter pylori tüm dünyada ve Türkiye’de en yaygin kronik enfeksiyon etkenidir ve ülkemizdeki prevalansi %80’ler civarindadir. Öncelikle mide mukozasina tutunarak çesitli gastroduodenal hastaliklara yol açmaktadir. Peptik ülser, gastrik MALT lenfoma, gastrik adenokanser gibi hastaliklari artirdigi bilinmekle birlikte, astim, eozinofilik özofajit ve çölyak hastaligi gibi bazi hastaliklara karsi da koruyucu olabilecegidüsünülmektedir. Biz de bu çalismamizda klinigimizde takipli çölyak hastalarinda Helicobacter pylori sikligini degerlendirmeyi amaçladik. Gereç ve Yöntem: Çalismaya histolojik inceleme ile tani almis 90 çölyak hastasi dahil edildi. Kontrol grubu olarak herhangi bir nedenle üst gastrointestinal sistem endoskopileri yapilarak biyopsileri yapilmis 108 hasta alindi. Hasta ve kontrol gruplarina ait veriler retrospektif olarak incelendi.Bulgular: Çölyak hastalari arasinda Helicobacter pylori 90 hastadan 37’sinde (%41.1) pozitif, kontrol grubunda 108 hastadan 63’ünde (%58.3)pozitif saptandi. Çölyak hasta grubunda Helicobacter pylori sikligi kontrol grubuna oranla anlamli olarak daha azdi (p: 0.016). Sonuç: Çölyakhastaligi olanlarda Helicobacter pylori sikligi literatür verileriyle de uyumlu olarak olmayanlara göre anlamli düzeyde düsük saptanmistir. Bu durumHelicobacter pylori varliginin çölyak hastaligi üzerine koruyucu etkileri olabilecegi yönündeki fikirleri desteklemektedir. Bu iliskinin netlestirilmesive olasi mekanizmalarin belirlenebilmesi için ileri çalismalara halen ihtiyaç duyulmaktadir.
Abstract
Background and Aims: Helicobacter pylori is the most common chronic infection agent all over the world and in Turkey, and its prevalence in our country is around 80%. It primarily penetrates the gastric mucosa, causing various gastroduodenal diseases. Although it is known to increase diseases such as peptic ulcer, gastric MALT lymphoma, gastric adenocancer, it is thought to be protective against some diseases such as asthma, eosinophilic esophagitis and celiac. In this study, we aimed to evaluate the frequency of Helicobacter pylori in celiac patients followed up in our clinic. Materials and Methods: Ninety celiac patients diagnosed with histological examination were included in the study. As the control group, 108 patients who underwent upper gastrointestinal system endoscopies and biopsies for any reason were included. The data of the patient and control groups were analyzed retrospectively. Results: Among celiac patients, Helicobacter pylori was positive in 37 (41.1%) of 90 patients, and positive in 63 (58.3%) of 108 patients in the control group. The frequency of Helicobacter pylori in the celiac patient group was significantly lower than in the control group (p: 0.016). Conclusion: The frequency of Helicobacter pylori in patients with celiac disease was found to be significantly lower than those without, which is consistent with the literature data. This supports the idea that the presence of Helicobacter pylori may have protective effects on celiac disease. Further studies are still needed to clarify this relationship and identify possible mechanisms.
