Nisan 2023
HbsAg seviyesinin HBV DNA ve karaciger fibrozisi ile iliskisi
The relationship of HbsAg level with HBV DNA and liver fibrosis
- Ana Sayfa
- Sayılar
- Nisan 2023
- HbsAg seviyesinin HBV DNA ve karaciger fibrozisi ile iliskisi...
Manisa Celal Bayar Üniversitesi Tip Fakültesi, 2Gastroenteroloji Bilim Dali, Manisa
Özet
Giris ve Amaç: Kovalent olarak kapali dairesel DNA düzeyinin kronik hepatit B hastalarinda hastaligin aktivitesini öngörmede klinik önemi bulunmaktadir. Kovalent olarak kapali dairesel DNA düzeyinin dolayli bir göstergesi olan hepatit B yüzey antijeni düzeyi, kronik hepatit B hastalarininyönetiminde hepatit B virüs-DNA düzeyi ile birlikte önemli rol alabilir. Çalismamizda, hepatit B nedeni ile karaciger biyopsisi yapilan hastalarinfibrozis skorlari, hepatit B virüs-DNA ve hepatit B yüzey antijeni seviyelerinin hepatit B zarf antijeni durumu dikkate alinarak kiyaslanmasiamaçlandi. Gereç ve Yöntem: 2017-2020 yillari arasinda kronik hepatit B nedeni ile karaciger biyopsisi yapilan hastalarin biyopsi sonuçlari,retrospektif kesitsel olarak degerlendirildi. Biyopsi sonucunda fibrozis degerleri hepatit B zarf antijeni durumu göz önüne alinarak degerlendirildi.Bulgular: Çalisma grubunu 71 (%55.4) erkek, 57 (%44.5) kadin toplam 128 hasta olusturdu. Ortalama yas erkeklerde 41.58 ± 14.27, kadinlarda43.63 ± 12.13 idi (p: 0.38). Hepatit B zarf antijeni pozitif hastalarda hepatit B yüzey antijeninin hepatit B virüs-DNA (p: < 0.01, r: 0.46), nekroinflamatuvar aktivite (p: 0.03, r: -0.38) ve fibrozis (p: < 0.01, r: -0.73) ile korele oldugu görüldü. Hepatit B zarf antijeni negatif hastalarda hepatit B yüzeyantijen seviyesi fibrozis ile iliskili olarak saptanmadi. Ancak ileri fibrozisi olan hastalarda hafif fibrozisi olanlara göre hepatit B virüs-DNA anlamliolarak yüksek (p: < 0.01) beraberinde hepatit B yüzey antijeni seviyeleri ise anlamli olarak daha düsük saptandi (p: < 0.01). Sonuç: Hepatit Byüzey antijeni seviyeleri hepatit B zarf antijeni pozitif hastalarda fibrozisi ön görmede faydali olmakla birlikte hepatit B yüzey antijeni negatif hastalarda fibrozisi öngörmede basarisi hepatit B zarf antijeni pozitif hastalar kadar iyi saptanmamistir
Abstract
Background and Aims: The level of covalently closed circular DNA has clinical significance in predicting the activity of the disease in patientswith chronic hepatitis B. Hepatitis B surface antigen level, which is an indirect indicator of covalently closed circular DNA level, may play an important role together with hepatitis B virus-DNA level in the management of chronic hepatitis B patients. In this study, it was aimed to compare thefibrosis scores, hepatitis B virus-DNA and hepatitis B surface antigen titers of the patients who underwent liver biopsy due to hepatitis B, takinginto account the hepatitis B e-antigen status. Materials and Method: Biopsy results of patients who underwent liver biopsy for chronic hepatitisB between 2017-2020 were evaluated retrospectively, cross-sectionally. Fibrosis values in biopsy results were evaluated considering Hepatitis Be-antigen status. Results: The study group consisted of 128 patients, 71 (55.4%) male and 57 (44.5%) female. The mean age was 41.58 ± 14.27in men and 43.63 ± 12.13 in women (p: 0.38). In hepatitis B e-antigen positive patients, hepatitis B surface antigen was found to be correlatedwith hepatitis B virus-DNA (p: < 0.01, r: 0.46), necroinflammatory activity (p: 0.03, r: -0.38) and fibrosis (p: < 0.01, r: -0.73). In hepatitis B e-antigennegative patients, hepatitis B surface antigen was not found to be associated with fibrosis. However, patients with advanced fibrosis had significantly higher hepatitis B virus-DNA (p: < 0.01) and hepatitis B surface antigen titers were significantly lower (p: < 0.01) compared to patients withmild fibrosis. Conclusion: Although hepatitis B surface antigen titers are useful in predicting fibrosis in hepatitis B e-antigen positive patients, itssuccess in predicting fibrosis in hepatitis B surface antigen negative patients was not as good as in hepatitis B e-antigen positive patients
