Giris ve Amaç: Bu çalismanin amaci çölyak hastaligi ile Helicobacter pylori enfeksiyonu arasindaki iliskiyi arastirmak ve modifiye Marsh skorunagöre eriskinlerde çölyak hastaligi ile Helicobacter pylori enfeksiyonunun siddetini karsilastirmaktir. Gereç ve Yöntem: Bu çalismaya 3. basamakbir hastanede tani alan 148 çölyak hastasi ve çesitli nedenlerle endoskopi yapilan 240 kontrol hastasi dahil edildi. Hastalarin yas, cinsiyet, endoskopi endikasyonlari, tanimlayici özellikleri, sikayetleri, serolojik, endoskopik ve histopatolojik bulgulari kaydedildi ve analiz edildi. Bulgular: Çölyak hastalarinda Helicobacter pylori kolonizasyonu %43.9, kontrol grubunda %57.5 idi (p = 0.009). Helicobacter pylori pozitiflik orani Marsh2, 3A, 3B, 3C gruplarinda anlamli olarak daha düsüktü (p = 0.04). Pearson korelasyon analizi, Helicobacter pylori’nin siddeti ile çölyak hastaligiarasinda zayif ancak anlamli negatif bir iliski ortaya koydu (r = -.109, p = 0.031). Marsh skoru arttikça Helicobacter pylori derecesi düstü. Sonuç:Mevcut çalisma, çölyak hastaligi olan eriskinlerde kontrol hastalarina göre Helicobacter pylori enfeksiyonu insidansinin daha düsük oldugunu veHelicobacter pylori kolonizasyon yogunlugunun çölyak hastalarinda daha hafif duodenal lezyonlarla iliskili oldugunu göstermistir. Helicobacterpylori kolonizasyonu, çölyak hastaliginin gelisiminde koruyucu bir role sahip olabilir
Background and Aims: The aim of this study was to investigate the relationship between celiac disease and Helicobacter pylori infectionand to compare the severity of celiac disease and Helicobacter pylori infection in adults according to the modified Marsh score. Materials andMethods: This study included 148 patients with celiac disease and 240 control patients without celiac disease who underwent endoscopy forvarious reasons in a tertiary hospital. Age, gender, endoscopy indications, descriptive characteristics, complaints, serological, endoscopic andhistopathological findings of the patients were recorded and analyzed. Results: Helicobacter pylori colonization in the celiac disease patientswas 43.9% and in control group was 57.5% (p = 0.009). Helicobacter pylori positivity rate was significantly lower in Marsh 2, 3A, 3B, 3C groups (p = 0.04). Pearson correlation analysis revealed a significant but weak negative relationship between the severity of Helicobacter pylori and celiacdisease (r = -.109, p = 0.031). When Marsh score was increasing, Helicobacter pylori grade decreased. Conclusion: The current study indicatedthat the incidence of Helicobacter pylori infection was lower in adults with celiac disease compared to control patients, and Helicobacter pyloricolonization density was associated with milder duodenal lesions in celiac patients. Helicobacter pylori colonization may have a protective role inthe development of celiac disease.