Nisan 2021
Ateroskleroz yayginligi ile kolon kanseri gelisimi arasinda iliski var mi?
Is there a relationship between the severity of atherosclerosis and the development of colon cancer?
- Ana Sayfa
- Sayılar
- Nisan 2021
- Ateroskleroz yayginligi ile kolon kanseri gelisimi arasinda iliski var mi?...
Özet
Giris ve Amaç: Kolorektal kanser ve ateroskleroz; erkek cinsiyet, Diabetes Mellitus, sigara içme ve obezite gibi yaygin risk faktörlerini paylasmaktadir. Aterosklerozun kolorektal kanser riskini belirlemede önemini anlamak üzere kolorektal kanser ve abdominal aorta aterosklerozu arasindaki iliskiyi arastirdik. Gereç ve Yöntem: Kolorektal kanser tanisialmis erkek hastalarin tani aldigi dönemdeki abdominal bilgisayarli tomografi incelemeleri degerlendirilmistir. Histopatolojik olarak kolorektal kanser tanisi konmasindan 3 ay önce ve 3 ay sonraki dönem araliginda yapilmis olan abdominal bilgisayarli tomografi incelemeleri olan 63 erkek hasta çalismaya dahil edilmistir. Ayrica çesitli nedenlerle abdominal bilgisayarli tomografi incelemesi yapilmis 56 erkek denek kontrol grubu olarak degerlendirilmistir. Abdominal bilgisayarli tomografi incelemelerinde sagittal reformat görüntüler üzerinden, L2, L3 ve L4 vertebralar seviyesinde, aorta ön ve arka duvarinda izlenen ateroskleroz skorlandirilmistir. Kolorektal kanseri bulunan ve kontrol grubu deneklerin abdominal aorta ateroskleroz skorlari karsilastirilmistir. Bulgular: Kolorektal kanseri bulunan hasta grubunun yas ortalamasi 63.95 ± 11.1, kontrol grubu deneklerin yas ortalamasi 64.79 ± 11.5 idi. Kolorektal kanseri olanlarda abdominal aorta ateroskleroz skor ortalamasi (5.44 ± 3.7), kontrol grubuna (3.86 ± 2.6) göre anlamli düzeyde daha yüksekti (p <0.05). Sonuç: Bu çalismada, kolorektal kanseri bulunan olgularda abdominal aortada ateroskleroz siddetinin kontrol grubuna kiyasla daha yüksek oldugu görüldü. Degisik nedenlerle yapilan abdominal bilgisayarli tomografi incelemelerinde aorta ateroskleroz skorlamasinin yapilmasi ile kolorektal kanser gelisim riski bakimindan degerli bilgi edinilebilecegini düsünmekteyiz.
Abstract
Background and Aims: Colorectal cancer and atherosclerosis share common risk factors, such as male gender, diabetes mellitus, smoking, and obesity. We investigated the relationship between colorectal cancer and atherosclerosis of the abdominal aorta to understand the importance of atherosclerosis in determining the risk of colorectal cancer. Materials and Methods: Sixty-three male patients with abdominal computed tomography examinations performed 3 months before and 3 months after the diagnosis were included in the study after being histopathologically diagnosed with colorectal cancer. In addition, 56 male subjects who had an abdominal computed tomography examination for various reasons comprised the control group. Atherosclerosis observed on the anterior and posterior wall of the aorta at the level of the L2, L3, and L4 vertebra was scored on sagittal reformatted abdominal computed tomography images. The abdominal aortic atherosclerosis scores of the subjects with colorectal cancer and the control group were compared. Results: The mean age of the patient group with colorectal cancer was 63.95 ± 11.1 years, and the mean age of the control group was 64.79 ± 11.5 years. The mean abdominal aorta atherosclerosis score (5.44 ± 3.7) was significantly higher in the patients with colorectal cancer than in the control group (3.86 ± 2.6) (p < 0.05). Conclusion: Abdominal aorta atherosclerosis was more severe in patients with colorectal cancer than in the control group. Valuable information on the risk of colorectal cancer development can be obtained by scoring aortic atherosclerosis on abdominal computed tomography scans performed for various reasons.
