Nisan 2020
Akut pankreatitte karbonhidrat antijen 19-9 seviyeleri
Carbohydrate antigen 19-9 levels in early acute pancreatitis
- Ana Sayfa
- Sayılar
- Nisan 2020
- Akut pankreatitte karbonhidrat antijen 19-9 seviyeleri...
Özet
Background and Aims: There are many etiologic factors responsiblefor acute pancreatitis. Carbohydrate antigen 19-9 is a well-known tumor marker for gastrointestinal malignancies, especially pancreaticobiliary cancer. Carbohydrate antigen 19-9 levels also increase benignevents such as cholestasis. Therefore, the purpose of this study is toretrospectively investigate the relationship between the underlyingetiologies and carbohydrate antigen 19-9 levels in patients who werehospitalized due to acute pancreatitis. Materials and Methods: Weretrospectively analyzed the data of 109 patients who had increasedcarbohydrate antigen 19-9 levels in the first 24 hours during hospitalization. Additionally, we divided the patients into two groups, namelybiliary and nonbiliary, based on their recent diagnoses in the etiologiesof acute pancreatitis. Results: We detected increased carbohydrate antigen 19-9 levels (more than 37 U/mL) in 63 (92%) of the patients inthe biliary group, and in 8 (19%) of the patients in the non-biliary group(p <0.001). There was a statistically significant difference between thegroups regarding the mean carbohydrate antigen 19-9 values (164.5vs. 24.1 U/mL, respectively; p <0.005). Also, aspartate aminotransferase, alanine aminotransferase, total bilirubin, and direct bilirubin valueswere statistically different between the two groups (p <0.05). The receiver operating characteristic curve analysis suggested that the optimum carbohydrate antigen 19-9 level cut-off point for the prediction ofpancreatitis caused by biliary reasons was 39.6 U/mL, with a sensitivityand specificity of 92.6% and 85.4%, respectively. Conclusion: Highlevels of carbohydrate antigen 19-9 (especially above 39.6 U/mL) inpatients with acute pancreatitis may be associated with biliary acutepancreatitis
Abstract
Background and Aims: There are many etiologic factors responsiblefor acute pancreatitis. Carbohydrate antigen 19-9 is a well-known tumor marker for gastrointestinal malignancies, especially pancreaticobiliary cancer. Carbohydrate antigen 19-9 levels also increase benignevents such as cholestasis. Therefore, the purpose of this study is toretrospectively investigate the relationship between the underlyingetiologies and carbohydrate antigen 19-9 levels in patients who werehospitalized due to acute pancreatitis. Materials and Methods: Weretrospectively analyzed the data of 109 patients who had increasedcarbohydrate antigen 19-9 levels in the first 24 hours during hospitalization. Additionally, we divided the patients into two groups, namelybiliary and nonbiliary, based on their recent diagnoses in the etiologiesof acute pancreatitis. Results: We detected increased carbohydrate antigen 19-9 levels (more than 37 U/mL) in 63 (92%) of the patients inthe biliary group, and in 8 (19%) of the patients in the non-biliary group(p <0.001). There was a statistically significant difference between thegroups regarding the mean carbohydrate antigen 19-9 values (164.5vs. 24.1 U/mL, respectively; p <0.005). Also, aspartate aminotransferase, alanine aminotransferase, total bilirubin, and direct bilirubin valueswere statistically different between the two groups (p <0.05). The receiver operating characteristic curve analysis suggested that the optimum carbohydrate antigen 19-9 level cut-off point for the prediction ofpancreatitis caused by biliary reasons was 39.6 U/mL, with a sensitivityand specificity of 92.6% and 85.4%, respectively. Conclusion: Highlevels of carbohydrate antigen 19-9 (especially above 39.6 U/mL) inpatients with acute pancreatitis may be associated with biliary acutepancreatitis
