Nisan 2019
Ülseratif kolitli hastalarda paraoksanaz 1 ve arilesteraz seviyeleri ve bu parametrelerin hastalik aktivitesi ile iliskileri
Paraoxonase 1 and arylesterase levels in patients with ulcerative colitis and their relationship with disease activity
- Ana Sayfa
- Sayılar
- Nisan 2019
- Ülseratif kolitli hastalarda paraoksanaz 1 ve arilesteraz seviyeleri ve bu parametrelerin hastalik aktivitesi ile iliskileri...
Atatürk Üniversitesi Tip Fakültesi, 2Gastroenteroloji Bilim Dali, Erzurum
Ahi Evran Üniversitesi Tip Fakültesi Hastanesi, 3Gastroenteroloji Klinigi, Kirsehir
Osmangazi Üniversitesi Tip Fakültesi, 4Gastroenteroloji Bilim Dali, Eskisehir
Özet
Giris ve Amaç: Bu çalismada ülseratif kolitli hastalarda serum paraoksonaz 1 ve arilesteraz düzeyleri ve bu parametrelerin hastalik aktivitesi ile iliskileri arastirildi. Gereç ve Yöntem: Çalismaya 38 aktif dönemde ülseratif kolit hastasi ve 38 saglikli kontrol grubu hastasi dahil edildi. Çalisma grubu hastalarindan hem aktif dönemde hem de remisyon saglaninca paraoksonaz 1 ve arilesteraz enzim aktiviteleri çalisildi. Paraoksonaz 1 ve arilesteraz enzim aktiviteleri aktif dönem, remisyon dönemi ve kontrol grubu arasinda kiyaslandi. Bulgular: Çalisma grubu hastalarinin yas ortalamasi 40.3±14.6 yil (19-78) olup hastalarin 20’si erkek (%52.6) ve 18’i kadin (%47.4) idi. Kontrol grubu hastalarinin demografik özellikleri çalisma grubuna benzerdi. Aktif dönemdeki ülseratif kolit hastalarinin ortalama serum paraoksonaz 1 degeri 65.8±15.0 U/L, ortalama serum arilesteraz degeri ise 151.0±236.6 U/mL olarak tespit edildi. Remisyon dönemindeki hastalarda ortalama serum paraoksonaz 1 degeri 82.4±58.4 U/L, ortalama serum arilesteraz degeri ise 94.1±134.6 U/ mL olarak tespit edildi. Kontrol grubundaki hastalarda ortalama serum paraoksonaz 1 degeri 131.7±63.5 U/L, ortalama serum arilesteraz de- geri ise 287.3±295.6 U/mL olarak tespit edildi. Ülseratif kolitli hastalarda ortalama paraoksonaz 1 ve arilesteraz düzeyleri aktif ve remisyon dönemi arasinda istatistiksel olarak anlamli fark göstermedi (p>0.05). Aktif ve remisyon dönemindeki ülseratif kolitli hastalarda ortalama paraoksonaz 1 ve arilesteraz degerleri kontrol grubundaki saglikli bireylere göre istatistiksel olarak anlamli sekilde düsük bulundu (p<0.05). Sonuç: Ülseratif kolitli hastalarda paraoksonaz 1 ve arilesteraz aktivitelerinin kontrol grubuna göre istatiksel olarak anlamli sekilde azaldigi ancak hastalik aktivitesi ile paraoksonaz 1 ve arilesteraz aktiviteleri arasinda iliski bulunmadigi gösterilmistir
Abstract
Background and Aims: In this study, we studied serum paraoxanase 1 and arylesterase levels in patients with ulcerative colitis and their relationship with disease activity. Material and Methods: Thirty-eight patients with active ulcerative colitis and 38 healthy controls were included in this study. Paraoxanase 1 and arylesterase enzyme activities in both active and remission phases were studied. Paraoxanase 1 and arylesterase enzyme activities in the active disease phase, the remission phase, and the control group were compared. Results: The mean patient age in the study group was 40.3±14.6 years (19-78); 20 patients were male (52.6%) and 18 were female (47.4%). The demographic characteristics of the patients in the control group were similar to those of the study group. The mean serum paraoxanase 1 level was 65.8±15.0 U/L, and the mean serum arylesterase level was 151.0±236.6 U/mL in patients in the active phase. The mean serum paraoxanase 1 level was 82.4±58.4 U/L, and the mean serum arylesterase level was 94.1±134.6 U/mL in patients in the remission phase. The mean serum paraoxanase 1 level was 131.7±63.5 U/L, and the mean serum arylesterase level was 287.3±295.6 U/mL in the control group. There was no statistically significant difference in mean paraoxanase 1 and arylesterase levels between patients in the active and remission phases (p > 0.05). The mean levels of paraoxanase 1 and arylesterase in patients in the active and remission phases were significantly lower than those in healthy controls (p < 0.05). Conclusion: In patients with ulcerative colitis, paraoxanase 1 and arylesterase enzyme activities were found to be significantly lower than those in the control group, but there was no relationship between disease activity and paraoxanase 1 and arylesterase enzyme activities
