Nisan 2019
Akut pankreatitli hastalarda serum endocan düzeyinin klinikle iliskisi: Serum endocan akut pankreatitte biyomarker olabilir mi?
Relationship between serum endocan levels and clinical follow-up in patients with acute pancreatitis: Can serum endocan be a biomarker for acute pancreatitis?
- Ana Sayfa
- Sayılar
- Nisan 2019
- Akut pankreatitli hastalarda serum endocan düzeyinin klinikle iliskisi: Serum endocan akut pankreatitte biyomarker olabilir mi?...
Saglik Bilimleri Üniversitesi, S.B. Derince Egitim ve Arastirma Hastanesi, 2Gastroenteroloji Klinigi, 4Biyokimya Bölümü, Derince, Kocaeli
S.B. Kargi Devlet Hastanesi, 3Iç Hastaliklari Bölümü, Kargi, Çorum
Özet
Giris ve Amaç: Akut pankreatit seyrinde hastaligin prognozunu tayin etmek için birçok belirteç ve skorlama sistemleri kullanilmaktadir. Bu çalismada endocan düzeyinin hafif ve siddetli pankreatit vakalarinda C-reaktif protein, Ranson skoru, revize Atlanta skorlamasi ve diger laboratuvar göstergeleri ile iliskisi karsilastirilarak prognozu öngörmede öneminin arastirilmasi planlanmistir. Gereç ve Yöntem: Çalismada 50 akut pankreatit hastasi prospektif olarak incelendi, basvuru ani, 2. ve 7. günlerde endocan, biyokimyasal parametreler ve C-reaktif protein degerleri ölçüldü. Hastalarin sikayet ile basvuru arasindaki zaman, yatis süreleri, skorlama sistemlerine göre pankreatit siddeti Ranson ve revize Atlanta skoru olarak kaydedildi. Verilerin istatistiksel analizinde SPSS 22.0 paket programi kullanildi. Bulgular: Hastalarin yas ortalamasi 61.36±16.21 yil olup olup %54’ü kadindi. Ranson skoruna göre 20 olgu (%30) siddetli pankreatit idi. Endocan degerleri hafif pankreatit grubu ve siddetli pankreatit grubu ile karsilastirildiginda basvuru aninda, 2. ve 7. günlerde anlamli sonuç vermemistir. Revize Atlanta skorlamasina göre siniflandi- rilan hasta gruplarinin serum endocan ile karsilastirilmasinda istatistiksel açidan fark görülmedi. Pankreatit siddeti için 2. gün bakilan C-reaktif protein siddetli pankreatitte ortalama 95.05 mg/L, hafif pankreatitte ise 77.06 mg/L olarak saptandi. Diger laboratuvar göstergelerinden alanin aminotransferaz, aspartat aminotransferaz, gama glutamil transferaz, alkalen fosfataz, total bilirübin ve direkt bilirübin hastaligin siddeti ile korele saptandi. Sonuç: Akut pankreatit prognozu ile endocan arasindaki iliskiyi daha net ortaya koymak için daha genis kapsamli prospektif çalismalara ihtiyaç vardir.
Abstract
Background and Aims: Several markers and scoring systems are used to determine the prognosis of acute pancreatitis. In this study, the role of endocan in predicting prognosis was investigated by comparing the relation between C-reactive protein, the Ranson score, the revised Atlanta classification, and other laboratory indicators in patients with mild and severe pancreatitis. Materials and Methods: Fifty acute pancreatitis patients were studied prospectively. Endocan, biochemical parameters, and C-reactive protein values were measured at the time of admission and on the second and seventh days. The time between complaints and patient admission, the length of stay, and the severity of pancreatitis according to the Ranson score and revised Atlanta classification were recorded. The SPSS 22.0 statistical package was used for data analysis. Results: The mean patient age was 61.36±16.21 years, and 54% of patients were female. According to the Ranson score, 20 cases (30%) had severe pancreatitis. When endocan levels in the mild and severe pancreatitis groups were compared at the time of application and at the second and seventh days, there were no statistically significant differences. There were no statistically significant differences in serum endocans between groups of patients classified according to the revised Atlanta scoring system. When patients were subdivided according to pancreatitis severity, the mean C-reactive protein levels on the second day were 95.05 mg/L in patients with severe pancreatitis and 77.06 mg/L in patients with mild pancreatitis. Other laboratory indices, such as alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, total bilirubin, and direct bilirubin, were correlated with disease severity. Conclusion: To clarify the relationship between the prognosis of acute pancreatitis and endocans, more extensive prospective studies are needed
