Nisan 2019
Kronik hepatit B hastalarinda ortalama trombosit hacmi, nötrofil/lenfosit orani ile fibrozis arasindaki iliski
Relationship between neutrophil-to-lymphocyte ratio, mean platelet volume, and fibrosis level in patients with chronic hepatitis B
- Ana Sayfa
- Sayılar
- Nisan 2019
- Kronik hepatit B hastalarinda ortalama trombosit hacmi, nötrofil/lenfosit orani ile fibrozis arasindaki iliski...
Özet
Giris ve Amaç:Karaciger biyopsisi kronik hepatit hastaliginda karacigerhasarini göstermek için halen altin standart yöntem olmakla beraber,günümüzde karaciger hasarini daha kolay belirleyebilmek için birçoknoninvaziv test arastirilmistir. Bu çalismada amacimiz kronik hepatit Bhastalarinda fibrozis belirteci olarak ortalama trombosit hacmi ve nötrofil lenfosit orani iliskisini arastirmaktir. Gereç ve Yöntem: Çalismaya44 kronik hepatit B hastasi ve 33 saglikli kisiden olusan kontrol grubualindi. Hasta ve kontrol gruplari arasinda karsilastirilmalar yapildi, ayricakronik hepatit B hastalari fibrozis skoruna göre hafif fibrozis ve ilerifibrozis olanlar olmak üzere iki gruba ayrilarak karsilastirmalar yapildi.Bulgular: Kronik hepatit B hastalarinin yas ortalamasi 43±16 ve kontrolgrubunun yas ortalamasi 41±19 idi. Kronik hepatit B grubunda ortalama trombosit hacmi 10.6±1.2 ve kontrol grubunda 9.5±0.6 bulundu.Bu iki grup arasinda istatistiksel fark oldugu görüldü (p=0.0001). Kronikhepatit B hastalari ve kontrol grubu arasinda nötrofil lenfosit oranlariarasinda anlamli fark saptanmadi (p=0.29). Fibrozis skoru hafif ve ileriolan hastalarin ortalama trombosit hacmi düzeyleri karsilastirildigindafibrozis skoru hafif olan hastalarda ortalama trombosit hacmi degerlerinin daha düsük oldugu görüldü (sirasiyla 9.7±0.4, 11.5±1.2; p=0.0001).ROC analizinde ortalama trombosit hacminin ileri fibrozisi saptanmasi-nin en iyi kesim degeri 10,25 alindiginda, sensitivitesi %86, spesifitesi%99 olarak bulundu (EAA 0.94; 95% CI; p<0.0001).Sonuç: Bu çalismaortalama trombosit hacmi degerinin kronik hepatit B hastalarinda artmis oldugunu ve artmis ortalama trombosit hacmi degerlerinin kronikhepatit B hastalarinda ileri fibrozisi tahmin etmede yardimci olabilece-gini göstermistir.
Abstract
Background and Aims: Hepatitis B virus infection remains a majorhealth problem worldwide. Although liver biopsy is the gold standardprocedure for documenting liver damage in chronic hepatitis, manynoninvasive tests have been investigated for the determination of liverdamage. The aim of this study was to evaluate the role of mean platelet volume and neutrophil lymphocyte ratio as markers of fibrosis inpatients with chronic hepatitis B. Material and Methods: The studyincluded 44 patients with chronic hepatitis B and 33 healthy subjectsas the control group. Demographic and laboratory data were recorded. Patients with chronic hepatitis B were compared with the controlgroup. Patients with chronic hepatitis B infection were then divided intotwo groups, mild fibrosis and advanced fibrosis, and these two groupswere compared. Results: The mean age of patients with chronic hepatitis B was 43±16 years, and the mean age of the control group was41±19 years. The mean platelet volume was 10.6±1.2 in the chronichepatitis B group and 9.5±0.6 in the control group. There was a statistically significant difference between the groups (p=0.0001). meanplatelet volume levels of patients with mild fibrosis were significantly lower than those of patients with advanced fibrosis (respectively,9.7±0.4, 11.5±1.2; p=0.0001). There was no statistically significantdifference in the neutrophil-to-lymphocyte ratio between the chronichepatitis B and control groups. Receiver operating characteristic curveswere used to assess advanced fibrosis in mean platelet volume andmean platelet volume. The cut-off value for the prediction of advancedfibrosis was 10.25, with a sensitivity and specificity of 86% and 99%,respectively (AUC 0.94; 95% CI; p < 0.0001). Conclusion: The presentstudy demonstrated that mean platelet volume is increased in chronichepatitis B, and high mean platelet volume levels may help to predictadvanced fibrosis in patients with chronic hepatitis B.
