Nisan 2019
Gögüs agrisi olan mitral kapak prolapsuslu çocuk hastalarda gastroözofageal reflü birlikteligi
Association of gastroesophageal reflux and chest pain in children with mitral valve prolapse
- Ana Sayfa
- Sayılar
- Nisan 2019
- Gögüs agrisi olan mitral kapak prolapsuslu çocuk hastalarda gastroözofageal reflü birlikteligi...
Karabük Üniversitesi Tip Fakültesi, 2Çocuk Gastroenterolojisi Bilim Dali, 4Çocuk Sagligi ve Hastaliklari Anabilim Dali, Karabük
Özet
Giris ve Amaç: Gögüs agrisi ve mitral kapak prolapsusu olan çocuklarda fonksiyonel gastrointestinal hastaliklarin gögüs agrisiyla iliskisiniarastiran az sayida çalisma vardir. Bu çalismada mitral kapak prolapsusuolan çocuklarda gögüs agrisi ve gastroözofageal reflü hastaligi arasindaki iliskiyi tanimlamayi amaçladik. Gereç ve Yöntem: Çalismaya, tipiküst gastrointestinal sistem semptomlari ve gögüs agrisi tanimlayan, hafif ile orta mitral kapak prolapsusu olan 70 çocuk hasta dahil edildi. Hastalar sekiz hafta süreyle anti-reflü ilaç tedavisi ile tedavi edildi. Tedaviden önce ve sonra hastalar gastroözofageal reflü hastaligi etki ölçegi iledegerlendirildi. Bulgular: Hastalarin yas ortalamasi 13.24±2.81 yildi ve42’si (%60) kizdi. 30 hastanin semptomlari 6 haftadan daha fazla ve 40hastanin semptomlari 6 haftadan az süredir mevcuttu. Tüm hastalarinortalama semptom süresi 8±2.2 haftaydi. En çok bildirilen semptom gö-güs agrisi (%89.9) ve ardindan regürjitasyon (%50) idi. Kronik gastroö-zofageal reflü olan çocuklarla karsilastirildiginda, yeni gastroözofagealreflü tanisi alan çocuklarda anlamli olarak daha sik ve ciddi semptomlar vardi. Mitral kapak prolapsusunun siddeti ile semptomlar arasindaanlamli bir iliski bulunmadi. Gastroözofageal reflü hastaligi etki ölçegiskorlari, tedaviden sonra tüm hastalarda istatistiksel olarak azalmisti (p<0.01). Her iki hasta grubu tedaviden fayda saglasa da, gastroözofageal reflü hastaligi yeni saptanan hastalar, kronik hastalardan daha fazlatedaviden fayda gördüler. Sonuç: Mitral kapak prolapsusu ve gögüsagrisi olan birçok çocuk hastada semptomatik gastroözofageal reflühastaligi mevcuttur. Gastroözofageal reflünün spesifik tanisi ve tedavisiçogu hastada gögüs agrisini hafifletmistir.
Abstract
Background and Aims: To date, few studies have investigated theassociation of pediatric functional gastrointestinal diseases with mitralvalve prolapse and chest pain. We aimed to describe the relationshipbetween chest pain and gastroesophageal reflux disease in childrenwith mitral valve prolapse. Materials and Methods: This study included 70 pediatric patients with mild-to-moderate mitral valve prolapsewith complaints of typical upper gastrointestinal system symptomsand chest pain. The patients were treated with medical anti-refluxdrug therapy for 8 weeks. Before and after treatment, the patientswere assessed with the Gastroesophageal Reflux Disease Impact Scale.Results: The mean patient age was 13.24±2.81 years, and 42 (60%)patients were female. The duration of symptoms in 30 patients waslonger than 6 weeks, and that of 40 patients was shorter than 6 weeks.The mean symptom duration of all patients was 8±2.2 weeks. The mostfrequently reported symptom was chest pain (89.9%), followed by regurgitation (50%). Compared with children who had chronic gastroesophageal reflux, children with recent, acute gastroesophageal refluxreported significantly more frequent and severe symptoms. There wasno significant relationship between the severity of mitral valve prolapseand symptoms. Gastroesophageal Reflux Disease Impact Scale scores ofall patients were significantly decreased after treatment (p < 0.01). Although both groups of patients benefited from treatment, it was foundthat patients with newly diagnosed gastroesophageal reflux diseasebenefited significantly more from treatment than patients with chronicdisease.Conclusion: Many preadolescents and adolescents with mitralvalve prolapse and chest pain had symptomatic gastroesophageal reflux disease. Specific diagnosis and therapy for gastroesophageal refluxdisease alleviated chest pain in most patients
