Giriş ve Amaç: Helicobacter pylori bölgemizde ve dünyada yüksek prevalansa sahip olup yaygin kronik inflamasyona neden olur. Biz bu çalis- mamizda D vitamini, hemogram parametreleri ve kan gruplari ile Helicobacter pylori arasında ilişki olabilecegini göstermeyi amaçladık. Gereç ve Yöntem: çalışmaya dispeptik sikâyetlerle iç hastalıklari poliklinigine başvurup endoskopi yapılan ve biyopsi ile Helicobacter pylori tanısı konan 91 hasta alındı. Hastalar Helicobacter pylori pozitif ve negatif olarak iki gruba ayrıldı. Demografik ve laboratuvar verileri hasta kayitlarindan elde edildi. Bulgular: Hastaların (n=91) yaş ortalaması 42.5±13 yıl, 70 (%76.9)’i kadın, 21 (%23.1)’i erkek ve 57 (%62.6)’si Helicobacter pylori pozitifti. Helicobacter pylori pozitif hastalarla negatif hastalar arasında yaş, beden kitle indeksi bakimindan istatiksel olarak anlamli fark vardı (sırasıyla P=0.001, P=0.048). Cinsiyet ile Helicobacter pylori arasında ilişki yoktu (Pearson Chi-Square r= 0.186, P=0.663). Helicobacter pylori enfeksiyonu tespit edilen hastalarda kandaki nötrofil, lenfosit sayisinda, nötrofil lenfosit oraninda belirgin azalma saptanmıştır ancak istatistiksel açidan sadece nötrofil sayisindaki düşüklük anlamlidir, sırasıyla (P <0.007, P=0.258, P=0.155). Helicobacter pylori tespit edilen hastalar negatif hastalarla karsilastirildiginda 25-OH D3 düzeyleri düşüktü (Pearson Chi-Square r= 3.95 and P=0.047). Helicobacter pylori ile kan gruplari ve Rh arasında korelasyon yoktu (sırasıyla Pearson Chi-Square r= 6.383 ve P=0.094, Pearson Chi-Square r= 0.131 ve P=0.717).Sonuç: Helicobacter pylori pozitif hastalardaki nötrofil sayisi, düşük serum vitamin D düzeyleri ile Helicobacter pylorinin yol açtigi kronik inflamasyona bagli olabilir.
Background and Aims: Helicobacter pylori infection is highly prevalent in developing countries, including Turkey, and causes widespread chronic inflammation. We suggest there may be an association between Helicobacter pylori infection and vitamin D, hemogram parameters, and blood group.Methods: In this study, 91 patients presented to an internal medicine outpatient clinic with dyspepsia and were found to have Helicobacter pylori infection by endoscopy. Patients were divided into two groups according to Helicobacter pylori positivity. Demographic and laboratory characteristics were obtained from medical records.Results: Mean age was 42.5±13 years; 77% were women, and 62.6% were Helicobacter pylori positive. Age and body mass index differed significantly between Helicobacter pylori positive and negative patients (P=0.001, P=0.048, respectively). There was no association between gender and Helicobacter pylori positivity (Pearson Chi-Square=0.186, P=0.663). Neutrophil, lymphocyte, and neutrophil lymphocyte ratio were remarkably lower in Helicobacter pylori positive patients but only the reduction in neutrophil counts was statistically significant (P < 0.007, P 0.258, P=0.155, respectively). Levels of 25-OH D3 were lower in patients who were Helicobacter pylori positive compared with those who were negative (Pearson Chi-Square 3.95, P=0.047). There were no associations between Helicobacter pylori positivity and blood group or Rh status (Pearson Chi-Square=6.383, P=0.094; Pearson Chi-Square=0.131, P=0.717, respectively). Conclusion: Low neutrophil counts in Helicobacter pylori positive patients might be due to interactions between low vitamin D levels and chronic inflammation caused by Helicobacter pylori.