Anti-tümör nekrozis faktör ajanlar, romatizmal hastaliklar ve inflamatuvar barsak hastaligi gibi farkli inflamatuvar durumlarda yüksek oranda etkili ilaçlardir. Bu ajanlara bagli olarak gelisen paradoksal yan etkilerle ilgili son yillarda, çogu vaka bildirimi seklinde olan yayinlar mevcuttur. Anti-tümör nekrozis faktör ajanlarin en sik kullanildigi romatizmal hastaliklardan birisi de ankilozan spondilittir. Biz bu yazida adalimumab kullanan ankilozan spondilitli bir hastada paradoksal olarak gelisen Crohn hastaligini sunmayi amaçladik
Anti-tumor necrosis factor agents are highly effective drugs for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Paradoxical side effects related with these agents have been reported in recent years, primarily as case reports. Ankylosing spondylitis is one of the rheumatoid diseases treated with adalimumab, a tumor necrosis factor inhibiting anti-inflammatory drug. In this report we describe the case of a patient with ankylosing spondylitis who developed Crohn’s disease, a paradoxical side effect in the use of adalimumab.