Amaç: Bu çalismada, fosfodiesteraz inhibitörü ve vazodilatatör bir ajan olan papaverinin hepatik iskemi reperfüzyon hasarina olan etkisini arastirmayi amaçladik. Yöntem: Çalisma, Dokuz Eylül Üniversitesi Deney Hayvanlari Laboratuari?nda yapildi. Çalismada yediserli üç gruba ayrilan toplam 21 adet disi Wistar albino tipi siçan kullanildi. Sham grubu (Grup 1): Sadece batin açilip kapatildi. Kontrol grubu (Grup 2): Karaciger portal triadi mikrovasküler klip ile kliplendi ve iskeminin 30. dakikasinda 20 mg/kg serum fizyolojik verildi. Çalisma (Papaverin) grubu (Grup 3): Ayni sekilde portal triad kliplendi ve iskeminin 30. dakikasinda 20 mg/kg papaverin uygulandi. Hem çalisma ve hem de kontrol grubunda altmis dakikalik iskemiyi takiben, 120 dakika reperfüzyon uygulandi. Olusan hasarin histopatolojik degerlendirilmesi Suzuki skorlama sistemine göre yapildi. Mikroskopik olarak; parankimde; hidropik sisme, granüler dejenerasyon, mikroveziküler vakuolizasyon, makroveziküler vakuolizasyon, fokal nekroz, kordon düzensizligi portal alanda ise; inflamasyon, fibrozis ve sinüzoidlerde ise hiperemi incelendi. Bulgular: Yapilan istatistiksel degerlendirme sonucu, parankimdeki fokal nekroz ve hidropik sisme hariç diger tüm ölçütlerde çalisma grubunda yer alan siçanlarin kontrol grubundakilere nazaran iskemi reperfüzyon hasarini anlamli derecede azalttigi saptandi. Sonuç: Bu çalismamizda papaverinin, hepatik iskemi reperfüzyon modelinde hasari azaltabilecegi sonucuna vardik.
Background and Aims: The present study aimed to investigate the in volvement of the phosphodiesterase inhibitor and vasodilator papaverine in hepatic ischemia-reperfusion injury. Materials and Methods: The study was conducted in the Experimental Animals Laboratory of Dokuz Eylül University. Totally, 21 female Wistar albino rats were divided into three groups as: (1) Sham Group: the abdomen was surgically opened and closed without any surgical procedure. (2) Control Group: the hepatic portal triad was clipped with microvascular clips and 20 mg/kg normal saline was administered 30 minutes after the ischemia. (3) Experimental (Papaverine) Group: the portal triad was clipped as described above and 20 mg/kg papaverine was administered 30 minutes after the ischemia. Sixty-minutes of ischemia followed by 120 minutes of reperfusion were induced in Groups 2 and 3. Histopathological evaluation of the damage was performed according to Suzuki?s scoring system. The sections were analyzed for hydropic swelling, granular degeneration, microvesicular vacuolization, macrovesicular vacuolization, and focal necrosis cord disorder in the parenchyma, for inflammation and fibrosis in the portal area, and for hyperemia in the sinusoids. Results: According to the statistical evaluation of our study, it was shown that ischemia-reperfusion injury was significantly reduced in the study group compared with the control in all parameters except focal necrosis and hydropic swelling. Conclusions: We concluded that papaverine may reduce damage in a hepatic ischemia-reperfusion model.