Aralik 2009
Gastroözofageal reflü hastalarinin klinik, endoskopik ve pH-metre verilerinin Helikobakter pilori enfeksiyonu ile iliskisi
Relationship between Helicobacter pylori infection and the clinical, endoscopic and pH-monitoring parameters of patients with gastroesophageal reflux disease
- Ana Sayfa
- Sayılar
- Aralik 2009
- Gastroözofageal reflü hastalarinin klinik, endoskopik ve pH-metre verilerinin Helikobakter pilori enfeksiyonu ile iliskisi...
Karadeniz Teknik Üniversitesi Tip Fakültesi 2Gastroenteroloji Bilim Dali, Trabzon
Özet
Giris ve Amaç: Gastroözofageal reflü hastalarinda yapilan bazi epidemiyolojik ve klinik çalismalarda Helikobakter pilori?nin reflü hastaligina karsi koruyucu oldugu bildirilirken, benzer sekilde düzenlenen baska çalismalarda bu etki gösterilememistir. Biz bu çalismamizda gastroözofageal reflü hastaligi olan hastalarda Helikobakter pilori?ye bagli korpus gastritinin; reflünün klinik, endoskopik ve pH-metre bulgularina etkisini arastirmayi planladik. Gereç ve Yöntem: Reflü tanisi konarak çalismaya alinan 40 hastanin epidemiyolojik ve klinik verileri kaydedildi. Pirozis ve regürjitasyonun siklik ve siddeti 0?dan 3?e kadar derecelendirildi. Antrum, korpus ve özofagus distalinden biyopsiler alindi. Ardindan hastalara 24 saatlik pH-metre izlemi uygulandi. Bulgular: Çalismaya alinan 40 hastanin 10 tanesi dislanma kriterleri nedeni ile çalismadan çikarildi. Kalan 30 hastanin 19 tanesinde korpus gastriti ve Helikobakter pilori pozitifligi, 22 tanesinde ise antral gastrit ve Helikobakter pilori pozitifligi saptandi. Helikobakter pilori?ye bagli korpus gastriti olan ve olmayan gruplar arasinda pH-metre toplam skoru, semptomlarin sikligi, siddeti ve süresi açisindan anlamli bir fark yoktu. Sonuç: Sonuç olarak; Helikobakter pilori?ye bagli korpus gastriti reflünün klinik, endoskopik ve pH-metrik sonuçlarini etkilememektedir.
Abstract
Background and Aims: While some of the epidemiologic and clinical studies performed in patients with gastroesophageal reflux disease reported that Helicobacter pylori infection may have a protective role against reflux disease, other similarly designed studies were unable to show this relationship. We planned to investigate the effects of Helicobacter pylori- associated corpus gastritis on the clinical and endoscopic findings and pH-monitoring parameters in patients with gastroesophageal reflux. Materials and Methods: After the diagnosis of gastroesophageal reflux disease, the clinical and epidemiologic data of 40 patients were recorded. The frequency and severity of heartburn and regurgitation were graded from 0 to 3. Biopsies were taken from antrum, corpus and distal part of the esophagus. Finally, patients underwent 24-hour esophageal pH monitoring. Results: Ten patients out of 40 were excluded from the study. The diagnosis of corpus gastritis and Helicobacter pylori infection was found in 19 patients, whereas antral gastritis and Helicobacter pylori infection was determined in 22 of the remaining 30 patients. No statistical significance was found between corpus gastritis-positive and -negative groups with regard to age, body mass index, total pH meter score, fraction time pH<4, and the frequency, severity and duration of symptoms. Conclusions: Helicobacter pylori-associated corpus gastritis does not influence the clinical findings and the pH meter measurements in reflux disease.
