Nisan 2008
Yillara göre duodenum ve mide ülserli olgularin ve bu olgulardaki Helikobakter pilori sikliginin irdelenmesi: Retrospektif 10 yillik irdeleme
Analysis of frequency of duodenal and gastric ulcer patients and frequency of Helicobacter pylori in these cases according to each year: A 10-year retrospective analysis
- Ana Sayfa
- Sayılar
- Nisan 2008
- Yillara göre duodenum ve mide ülserli olgularin ve bu olgulardaki Helikobakter pilori sikliginin irdelenmesi: Retrospektif 10 yillik irdeleme...
Özet
Giris ve Amaç: Bu çalismanin amaci, üst gastrointestinal sistem endoskopisi yapilan olgular içinde duodenum ve mide ülseri ve bu olgulardaki Helikobakter pilori sikligini yillara göre irdelemektir. Gereç ve Yöntem: Temmuz 1996-Haziran 2005 tarihleri arasinda Ege Üniversitesi Tip Fakültesi Gastroenteroloji Klinik arsivine ait tüm üst gastrointestinal endoskopi kayitlari incelenmistir. Duodenum ve mide ülserli olgularin sikligi beser yillik dönemler ve yillara göre ayri ayri degerlendirilmistir. Helikobakter pilori varligi hizli üreaz testi ile degerlendirilmistir. Duodenum ve mide ülseri sikligini saptamak için tüm ülserli olgular degerlendirmeye alinirken, Helikobakter pilori pozitifligi sikligini saptamak için, kayitlarda üreaz testi sonucu bulunan olgular degerlendirilmistir. Bulgular: 1996-2005 yillari arasinda toplam 35957 endoskopi yapilmistir. Olgularin 1677 (%4.6)’sinde mide ülseri, 4281 (%11.9)’sinde de duodenum ülseri saptanmistir. Beser yillik dönemler ve yillara göre ayri ayri degerlendirildiginde, mide ülseri sikliginda anlamli bir degisiklik olmadi- gi saptanmis, ancak duodenum ülseri sikliginda azalma oldugu dikkati çekmistir. Hem beser yillik dönemler hem de yillara göre ayri ayri degerlendirildiginde, duodenum ülserli olgulardaki Helikobakter pilori sikliginda azalma oldugu saptanmistir. Mide ülserli olgulardaki Helikobakter pilori sikliginda yillara göre degerlendirildiginde fark saptanmamis, ancak bu olgularda ikinci 5 yillik perioddaki Helikobakter pilori sikliginda azalma oldugu dikkati çekmistir. Sonuç: Ikinci bes yillik periodda mide ülserli olgularda Helikobakter pilori pozitifligi yönünden anlamli bir azalma olmasina karsin, mide ülseri görülme sikliginda belirgin bir azalma saptanmamistir. Bu durumun, mide ülseri etyopatogenezinde önemli bir rolü olan nonsteroidal anti-inflamatuvar ilaçlarin kullaniminin artisi ile iliskili olabilecegi düsünülmüstür. Diger taraftan duodenum ülseri sikligi ve bu olgulardaki Helikobakter pilori sikligi belirgin olarak azalmaktadi r. Duodenum ülseri sikliginin yillara göre giderek azaliyor olmasi, Helikobakter pilorinin eradikasyonu ile iliskili olabilir.
Abstract
Background and aims: The aim of this study was to evaluate the frequency of the duodenal and gastric ulcer in cases underwent to upper gastrointestinal endoscopy according to each year, and to evaluate the frequency of Helicobacter pylori in these cases with ulcers. Material and Methods: All of the upper gastrointestinal endoscopy reports from archieve of Department of Gastroenterology, Ege University Medical School between July-1996 and June-2005 were searched. The frequency of the cases with duodenal and gastric ulcer were analyzed according to each year and to the 5-year periods. The presence of Helicobacter pylori was diagnosed by rapid urease test. All of the cases with duodenal and gastric ulcer were evaluated in order to detect the frequency of ulcer, and only cases with urease test result were included into the assessment in order to detect the frequency of Helicobacter pylori. Results: Overall, 35957 endoscopies were performed betweeen 1996 and 2005. Of these, duodenal ulcer was found in 4281 (11.9%), and gastric ulcer in 1677 (4.6%) cases. There was no difference in gastric ulcer frequencies according to each year and to the 5-year periods, however, a decrease was observed in frequency of duodenal ulcer. Helicobacter pylori frequency in duodenal ulcer cases decreased according to each year and to the 5-year periods. In gastric ulcer cases, although there was no difference in Helicobacter pylori frequency according to each year, Helicobacter pylori frequency was found to be lower in the latter 5-year period. Conclusions: Although there was no difference in frequency of gastric ulcer in the latter 5-year period, a decrease was observed in frequency of Helicobacter pylori in these cases. This may be explained by an increase in the use of non steroidal anti inflammatory drugs which play an important role in gastric ulcer etiopathogenesis. On the other hand, there was a decrease in frequency of duodenal ulcer and also frequency of Helicobacter pylori in these cases. This may be explained by the eradication of Helicobacter pylori.
