Aralik 2007
Gluten enteropatisi sikligi
The frequency of gluten enteropathy disease
- Ana Sayfa
- Sayılar
- Aralik 2007
- Gluten enteropatisi sikligi...
Özet
Giris ve Amaç: Çölyak hastaligi tüm dünyada yaygin olarak görülen ve sebep olugu siddetli enteropati glutensiz diyetle düzelebilen bir hastaliktir. Toplumdaki tarama çalismalarinda en yaygin yöntem, ilk adimda hasta serumunda antigliadin antikorlarini arastirmak, daha sonrasinda ise anti endomisyum antikorlarin varligini belirlemektir. Çalismamizin amaci, bölgemizdeki çölyak hastaligi sikligini tespit etmektir. Gereç ve Yöntem: Çalismaya yaslari 7 ile 14 arasinda degisen 194 çocuk (104 kiz, 90 erkek, ort. yas 9.8 yil) katildi. IgA ve IgG tipinde antigliadin antikorlari ELISA yöntemiyle, antigliadin antikoru pozitif olanlarda da anti endomisyum antikoru ise, Euroimmun titerplane technique (Medizinische Laboradiagnostika) yöntemiyle bakildi. Bulgular: 43 ögrencinin antigliadin antikoru IgA?si pozitif, 21 ögrencinin antigliadin antikoru IgG?si pozitif ve sadece bir ögrencinin anti endomisyum antikoru antikorlari pozitif bulundu. Antigliadin antikorlarinin hassasiyet ve özgüllügü sirasiyla %100, %87, anti endomisyum antikoru hassasiyet ve özgüllügü ise %100 olarak bulundu. Sonuç: Yöremizde çölyak hastaligi sikligi %0.51 olup, dünyadaki oranlardan oldukça düsüktü. Bulgularimiz ilerde yapilacak çölyak hastaligi taramalarinda antikor tespitinin yararlari- ni göstermistir. Örnekleme sayimizda belirledigimiz oranlari, tüm popülasyona genelleyebilmek için yeterli olmadigi halde, bu tür bir çalisma, bölgede yapilacak diger arastirmalara yol göstermesi açi- sindan önem tasimaktadir.
Abstract
Background and Aims: Celiac disease represents a significant health problem worldwide in identified patients; however, the severe enteropathy of celiac disease can be controlled with a gluten-free diet. Population screening studies using IgA/IgG antigliadin antibody determinations in patient serum as the first step and evaluation of the antigliadin antibody- positive subjects by IgA class anti-endomysium antibody tests as the second step has been the most common screening schedule. The aim of this study was to assess the prevalence of celiac disease in our local area. Materials and Methods: One hundred ninety-four students (104 girls, 90 boys, mean age 9.8 years) were enrolled in the study. Ages ranged from 7 to 14 years. Antigliadin antibodys of both IgG and IgA classes were measured by enzyme-linked immunosorbent assay and IgA class anti-endomysium antibody was measured in antigliadin antibody - positive cases by Euroimmune titerplane technique (Medizinische Laboradiagnostika). Results: Antigliadin antibody-IgA were positive in 43 students, antigliadin antibody - IgG were positive in 21 students and only one student was positive for anti-endomysium antibody. Sensitivity and specificity for antigliadin antibody were 100% and 87%, respectively, and for anti-endomysium antibody were 100% and 100%, respectively. Conclusions: Prevalence of celiac disease in the study population was 0.51%. This value is less than in other countries. The findings suggest the importance of the primary testing of autoantibodies in future celiac disease screening policies in this area. Although the number of the studied population was insufficient for generating the results to the entire population, it will be a guide for future evaluations in our region.
