Behçet hastaliginda üst gastrointestinal sistem bulgulari ve Helikobakter pilori sikligi
Upper gastrointestinal system findings and Helicobacter pylori frequency in patient’s with Behçet’s disease
- Ana Sayfa
- Sayılar
- Behçet hastaliginda üst gastrointestinal sistem bulgulari ve Helikobakter pilori sikligi...
Özet
Giris ve amaç: Behçet hastaligi agiz mukozasinda ülserasyonlar, göz lezyonlari, genital ülserasyonlar ve paterji testi pozitifligi ile karakterize, etyolojisi kesin olarak belli olmayan, kronik tekrarlayici bir hastaliktir. Hastalik agizdan anüse kadar gastrointestinal kanalin herhangi bir kismi- ni etkileyebilir. Helikobakter pilori (Hp) enfeksiyonu, dünyadaki en yaygi n bakteriyel gastrointestinal hastalik olup, duodenal ve mide ülserinin patogenezinde rol oynamaktadir. Bizim amacimiz bölgemizde yasayan behçetli hastalardaki endoskopik olarak gastrointestinal patolojilerin sikli gini ve Hp ile iliskisini arastirmaktir. Gereç ve yöntem: Çalismamiza Behçet hastaligi tanisi almis 21 hasta (12 erkek, 9 kadin) dahil edildi. Dispeptik yakinmalari sebebiyle tüm hastalara üst gastrointestinal sistem endoksopisi uygulandi. Hp varligini gösterebilmek amaciyla mide antrum, angulus yayi ve korpustan biyopsiler alindi. Bulgular: Hastalarimi- zin yas ortalamasi 36±7.7 yil (24-52), ortalama hastalik süresi 60.5±75.8 ay (1-324) idi. Endoskopik inceleme sonucu hastalarimizin tümünde gastrit (% 100), 3’ünde (% 14.2) özofajit. 5’inde (% 23.8) mide ülseri, 11’ inde duodenit (% 52.3) tespit ettik. Histopatolojik inceleme sonucu 16 hastada (% 76.1) Hp pozitif kronik gastrit, 5 hastada (% 23.8) Hp negatif kronik gastrit bulundu. Kontrol grubunun 9’unda (% 42.8) tespit edilebilen Hp pozitiflik orani ile aralarinda istatistiksel olarak anlamli iliski tespit edildi.(p:0.028) Hastaligin aktif dönemde oldugu 6 hastanin hepsinde histopatolojik olarak Hp (+) kronik aktif gastrit tespit edildi. Sonuç: Behçet tanisiyla takip edilen ve dispeptik sikayetleri olan hastalara üst gatsrointestinal sistem endoskopisi yapilmalidir. Hastaligi aktif dönemde olan dispeptik sikayetlere sahip hastalara, eger endoskopi ihtimali yoksa Hp eradikasyonu uygulanmalidir.
Abstract
Background/aim: Behçet’s disease (BD) is a chronic recurrent systemic disease of unknown etiology characterized by the presence of oral ulceration, eye lesions, and positive pathergy test. Gastrointestinal system involvement may affect all areas from the esophagus to the anus. Helicobacter pylori (Hp) infection is the most common bacterial gastrointestinal infection worldwide and has a role in duodenal and gastric ulcer disease. In this study, we aimed at studying the frequency of gastrointestinal pathologies endoscopically and that of Hp in patients with Behçet’s disease living in our region. Materials and methods: Twenty one patients (12 male, 9 female) who met the diagnostic criteria of the international study group for Behçet’s disease were included in our study. Upper gastrointestinal endoscopy was performed in all patients because of dyspeptic complaints. Biopsies were taken to indicate the occurrence of Hp from gastric antrum, corpus and angulus. Results: The mean age of patients was 36±7.7 years (24-52). Their mean disease intervals were 60.5±75.8 months (1-324). Endoscopic examinations showed esophagitis in 3 patients (14.2%), gastric ulcer in 5 patients (23.8%), duodenitis in 11 patients (52.3%), and gastritis in all patients (100%). Histopathological investigations revealed Hp-positive chronic active gastritis in 16 patients (76.1%), and Hp-negative chronic gastritis in 5 patients (23.8%). There was a statistically significant relation when patients were compared with Hp positivity rate detected in 9 of control group. Histopathologically Hp (+) chronic gastritis was detected in all 6 patients with active disease. Conclusion: Upper gastrointestinal endoscopy should be done in Behçet’s disease patients with dyspeptic complaints. Hp eradication should be applied to patients with dyspeptic complaints and with active disease if there is no opportunity for endoscopy.
