Nisan 2017
Helicobacter pylori enfeksiyonunun D vitamini, hemogram parametreleri ve kan grubu ile iliskisi
Association of Helicobacter pylori infection with vitamin D, hemogram parameters, and blood group
- Ana Sayfa
- Sayılar
- Nisan 2017
- Helicobacter pylori enfeksiyonunun D vitamini, hemogram parametreleri ve kan grubu ile iliskisi ...
2Sakarya Üniversitesi Egitim ve Arastirma Hastanesi, Iç Hastaliklari Klinigi, Sakarya
Özet
Giris ve Amaç: Helicobacter pylori bölgemizde ve dünyada yüksek prevalansa sahip olup yaygin kronik inflamasyona neden olur. Biz bu çalis- mamizda D vitamini, hemogram parametreleri ve kan gruplari ile Helicobacter pylori arasinda iliski olabilecegini göstermeyi amaçladik. Gereç ve Yöntem: Çalismaya dispeptik sikâyetlerle iç hastaliklari poliklinigine basvurup endoskopi yapilan ve biyopsi ile Helicobacter pylori tanisi konan 91 hasta alindi. Hastalar Helicobacter pylori pozitif ve negatif olarak iki gruba ayrildi. Demografik ve laboratuvar verileri hasta kayitlarindan elde edildi. Bulgular: Hastalarin (n=91) yas ortalamasi 42.5±13 yil, 70 (%76.9)’i kadin, 21 (%23.1)’i erkek ve 57 (%62.6)’si Helicobacter pylori pozitifti. Helicobacter pylori pozitif hastalarla negatif hastalar arasinda yas, beden kitle indeksi bakimindan istatiksel olarak anlamli fark vardi (sirasiyla P=0.001, P=0.048). Cinsiyet ile Helicobacter pylori arasinda iliski yoktu (Pearson Chi-Square r= 0.186, P=0.663). Helicobacter pylori enfeksiyonu tespit edilen hastalarda kandaki nötrofil, lenfosit sayisinda, nötrofil lenfosit oraninda belirgin azalma saptanmistir ancak istatistiksel açidan sadece nötrofil sayisindaki düsüklük anlamlidir, sirasiyla (P <0.007, P=0.258, P=0.155). Helicobacter pylori tespit edilen hastalar negatif hastalarla karsilastirildiginda 25-OH D3 düzeyleri düsüktü (Pearson Chi-Square r= 3.95 and P=0.047). Helicobacter pylori ile kan gruplari ve Rh arasinda korelasyon yoktu (sirasiyla Pearson Chi-Square r= 6.383 ve P=0.094, Pearson Chi-Square r= 0.131 ve P=0.717).Sonuç: Helicobacter pylori pozitif hastalardaki nötrofil sayisi, düsük serum vitamin D düzeyleri ile Helicobacter pylorinin yol açtigi kronik inflamasyona bagli olabilir.
Abstract
Background and Aims: Helicobacter pylori infection is highly prevalent in developing countries, including Turkey, and causes widespread chronic inflammation. We suggest there may be an association between Helicobacter pylori infection and vitamin D, hemogram parameters, and blood group.Methods: In this study, 91 patients presented to an internal medicine outpatient clinic with dyspepsia and were found to have Helicobacter pylori infection by endoscopy. Patients were divided into two groups according to Helicobacter pylori positivity. Demographic and laboratory characteristics were obtained from medical records.Results: Mean age was 42.5±13 years; 77% were women, and 62.6% were Helicobacter pylori positive. Age and body mass index differed significantly between Helicobacter pylori positive and negative patients (P=0.001, P=0.048, respectively). There was no association between gender and Helicobacter pylori positivity (Pearson Chi-Square=0.186, P=0.663). Neutrophil, lymphocyte, and neutrophil lymphocyte ratio were remarkably lower in Helicobacter pylori positive patients but only the reduction in neutrophil counts was statistically significant (P < 0.007, P 0.258, P=0.155, respectively). Levels of 25-OH D3 were lower in patients who were Helicobacter pylori positive compared with those who were negative (Pearson Chi-Square 3.95, P=0.047). There were no associations between Helicobacter pylori positivity and blood group or Rh status (Pearson Chi-Square=6.383, P=0.094; Pearson Chi-Square=0.131, P=0.717, respectively). Conclusion: Low neutrophil counts in Helicobacter pylori positive patients might be due to interactions between low vitamin D levels and chronic inflammation caused by Helicobacter pylori.
